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24 Cards in this Set
- Front
- Back
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malignancies that arise from lymphoid cells that reside in lymphoid tissue outside of the marrow
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lymphoma
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malignancies which are blood and marrow based
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leukemia
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lymphomas are divided into 2 major categories
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Hodgkin lymphoma and non-Hodgkin lymphoma
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the most common group of lymphomas
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B cell non-Hodgkin lymphomas
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Grade 1
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small cleaved cells
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Are grade 1 B-NHL's considered low or high grade? Are they more or less aggressive?
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Grade 1 - low grade
indolent, less aggressive |
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Grade 3
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large cells
more aggressive |
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t(14;18)
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follicular lymphoma
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translocation that results in over expression of Bcl-2, an anti-apoptotic gene
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t(14;18)
follicular lymphoma |
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CD20 and CD10 positive with t(14;18) is suggestive of
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follicular lymphoma
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tissue counterpart to CLL
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small lymphocytic lymphoma (SLL)
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translocation 8;14 is associated with
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Burkitt lymphoma
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highly aggressive, endemic in Africa, Epstein-Barr virus thought to play a role
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Burkitt lymphoma
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demonstrates diffuse proliferation of small noncleaved cells with a very high mitotic rate, background of "starry sky" macrophages
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Burkitt lymphoma
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diagnosis of exclusion, does not express CD10, CD5, or CD23, neoplastic proliferation of B cells from the marginal zone
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low grade B cell lymphoma of MALT
or MALT lymphoma |
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often presents as a rapidly growing anterior mediastinal mass in young patients, especially males
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precursor T-lymphoblastic lymphoma
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tumor of small, skin-based T cells
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Mycosis Fungoides
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produces a band like superficial dermal infiltrate
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Mycosis Fungoides
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epidermotropisms and Pautrier's microabscesses of the skin are characteristic features of
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Mycosis Fungoides, tumor of small skin-based T cells
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usually a nodal disease of adults with a loss or aberrant expression of a T cell antigen that its supposed to make normally
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peripheral T-cell lymphoma
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Reed-Sternber cell or "owl eyes" is associated with
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Hodgkins lymphoma
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CD15+, CD30+, CD45-
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Hodgkin lymphoma
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characteristic reactive inflammatory cells with an admixed smaller population of large dysplastic RS cells
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Hodgkin lymphoma
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lymphocyte predominance is the nonclassical Hogkins form which differs from the classical form in that it
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has a characteristic immunophenotype of CD45+, CD15-, CD30-, CD20+ and the prognosis is excellent
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