Lymphoid Tissues And Organs

Front 1

B Lymphocytes

Back 1

Involved in the production of antibodies= humoral immunity

Front 2

T Lymphocytes

Back 2

differentiate in the thymus and involved in cell mediated immunity

Front 3

Helper CD4+ T Cells

Back 3

cells that express CD4 markers and have the ability to secrete cytokines.

Front 4

Cytotoxic CD8+ T cells

Back 4

Kill virus infected cells, cancer cells and transplanted cells

Front 5

Suppressor T cells

Back 5

Regulate T cell activity

Front 6

Gamma/delta T cells

Back 6

neither CD8+ nor CD4+ surface markers; strategically positioned at interfaces of internal and external environments and act as the first line of defense against invaders

Front 7

Cluster of differentiation molecules

Back 7

Cell surface molecules visualized with immunohistochemical techniques using monoclonal antibodies; expressed at certain stages of differentiation

Front 8

Natural Killer cells (NK)

Back 8

specialized to kill certain types of target cells, usually targets that were transformed by viruses or neoplasia

Front 9

What do NK cells release and what does it do?

Back 9

Perforin and granzymes that cause targets to undergo apoptosis.

Front 10

Antigen Presenting Cells

Back 10

Must "present" CD4+ T helper cells with antigen in order for helper T cell to recognize it

Front 11

Cells of the Mononuclear Phagocytic System

Back 11

Macrophages, Perisinusoidal macrophages, Langerhans cells of the epidermis, dendritic cells of the spleen and lymph nodes

Front 12

APCs not in the MPS?

Back 12

B lymphocytes and epithelioreticular cells (II and III)

Front 13

MHC

Back 13

Major histocompatibility gene produces molecules that are specific to the individual and the specific tissue type & cell differentiation

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MHC-I

Back 14

Present on the surface of all nucleated cells and platelets; targets elimination of abnormal host cells.

Front 15

MHC-II

Back 15

Limited distribution; presents partially digested foreign peptides to helper T cells

Front 16

Location of MALT?

Back 16

aka diffuse lymphatic tissue; found in the loose connective tissue underlying the epithelia in lamina propria

Front 17

Function of MALT

Back 17

contains numerous plasma cells and eosinophils

Front 18

Nodular lymphatic tissue

Back 18

discrete concentration of lymphocytes in meshwork of reticular cells

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Primary nodules

Back 19

contain small lymphocytes

Front 20

Secondary nodules

Back 20

lightly-stained germinal center with numerous large lymphocytes and plasmablasts & follicular dendritic cells

Front 21

What is the recognizable feature of a lymphatic nodule on a stain?

Back 21

Lightly stained germinal center because of large amount of immature cells and their spread out euchromatin.

Front 22

GALT

Back 22

Gut Associated Lymphatic Tissue-- a type of MALT; specialized accumulations of lymphatic nodules found in various places of gut

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Tonsils

Back 23

Form a protective ring of lymphatic tissue around the posterior aspect of the oral cavity called "Waldeyer's ring"

Front 24

Palatin tonsils

Back 24

either side of posterior oral cavity between the palatoglossal and palatopharyngeal arches

Front 25

Lingual tonsils

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In the base of the tongue

Front 26

Pharyngeal tonsils

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In the roof of the pharynx called "adenoids"

Front 27

Peyer's Patches

Back 27

located on the anti-mesenteric side of ileum containing T and B lymphocytes

Front 28

Appendix

Back 28

heavily infiltrated with lymphocytes, no longer considered vestigial

Front 29

Lymph nodes

Back 29

Small, bean-shaped, encapsulated organs located along lymphatic vessels; act as filters

Front 30

Afferent lymphatic vessel

Back 30

Convey lymph toward the convex node

Front 31

Efferent lymphatic vessel

Back 31

Convey lymph away from the node

Front 32

Stroma

Back 32

supporting connective tissues forming a network around lymph nodes made up of reticular fibers

Front 33

Hilum

Back 33

Region where artery enters and vein and efferent lymphatic vessels exit

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Medulla

Back 34

Innermost portion of node; contains cords of cells that are separated by medullary sinuses

Front 35

Cortex

Back 35

Inner and outer cortex, both contain nodules

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Capsule

Back 36

Made of connective tissue extending trebeculae of CT

Front 37

High endothelial venues (HEVs)

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function to draw water out of the lymph into the blood stream, high concentration of aquaporin.

Front 38

Cause of reactive lymphadenitis?

Back 38

Bacterial infections, cat scratch

Front 39

Thymus

Back 39

Site of T-cell education

Front 40

Contents of the thymus?

Back 40

Populated with multi potential lymphoid stem cells

Front 41

Function of the trabecular of the thymus?

Back 41

Demarcate lobules

Front 42

Hassal's corpuscular

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Giant pink cell formed of epithelial and granules; eosinophilic

Front 43

What is the blood-thymus barrier?

Back 43

A physical barrier to prevent antigens from reaching developing T-cells in the cortex

Front 44

Thymic follicular hyperplasia

Back 44

Follicles with germinal centers appear in the thymus

Front 45

Spleen

Back 45

Largest, fist sized, lymphatic organ that filters blood

Front 46

Function of the spleen

Back 46

Blood borne antigen presentation by APC, hemopoietic; retrieval of iron from RBCs and stores blood