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18 Cards in this Set
- Front
- Back
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Lyme Disease etiologic agent: (what's the bug?)
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Borrelia burgdorferi
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What are the distinctive features of Borrelia burgdorferi?
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-Unicellular organism
-Loosely coiled lefthand helix -Can pass thru most bacteriological filters -Gram neg -Microaerophilic |
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Borrelia burgdorferi VECTOR
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Ixodes dammini
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what is Ixodes dammini?
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The deer tick
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What do we call the type of structure that is the Borrelia burgdorferi species?
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Spirochete
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What are the skin lesions caused by borrelia burgdorferi called?
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Erythema chronicum migrans
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What are the 2 effects that cause the resulting pathology of lymes disease?
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1. Accumulation of immune complexes in joints
2. O-antigen stimulation of interleukin-1 from macrophages |
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What results from immune complex accumulation in joints?
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Attraction of neutrophils and erosion of bone and cartilage; thus arthritis-like symptoms.
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Type of antigen on Borrelia:
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O-antigen
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What does the presence of O-antigen in the body stimulate?
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Macrophages to secrete IL-1
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Result of IL-1 stimulation:
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Stimulated production of Collagenase and Prostaglandin
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Result of Collagenase and Prostaglandin increases:
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-Collagen breakdown
-Pain |
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3 clinical symptom stages of lymes disease:
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1. Rash
2. Neurological 3. Arthritis |
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Time from of the Rash stage:
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2-30 days after bite
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Features of the rash stage:
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-A large bull's eye rash expands radially from the tickbite
-Noticeable swelling at center -Fatigue, fever, chills, headache, and backache |
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Features of the Neurological stage of lyme's disease:
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-Neurological complication
-Migrating musculoskeletal pain |
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Primary symptoms of the Arthritis stage of Lyme's disease:
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Joint problems similar to those in rheumatoid arthritis, lasting from several months to 2 years after rash stage.
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Most effective antibiotics for treating Lyme disease:
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-Doxycycline
-Amoxicillin -Ceftriaxone -Cefuroxime -Clarithrimycin |
