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24 Cards in this Set
- Front
- Back
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Lupus patients produce what kind of autoantibodies?
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antinuclear antibodies
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What are patient epidemiologic trends seen with lupus?
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female>male
black>white hispanics and chinese affected often. low socioeconomic ppl affected |
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what gene abnormalities are associated?
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deficiency in DR2, DR3, and C4A
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what makes up for the discordance of identical twins with lupus?
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exposure to secondary risk factors like infection, hormones, and UV radiation
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what lesions are seen that you can biopsy?
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vasculitis, vascular leukocclusion, and thrombosis from anti phospholipid antibody
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What are the eleven traits that are possible with lupus (to be diagnosed you need to have four)?
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serositis, oral ulcers, arthritis, photosensitive rash, blood dyscrasias, renal disorder, ANA, immunologic disorder, neurologic disorder, malar rash, discoid rash.
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what trait distinguishes lupus oral ulcers from others?
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they are painless
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arthritis in lupus is clinically indistinguishable from what?
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RA
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Jaccoud's arthropathy seen in RA and lupus is do to what?
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ligamentous laxity
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what blood dyscrasias are seen?
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hemolytic anemia with reticulocytosis (pt's are coomb;s positive, an Ab against RBC's), leukopenia, lymphopenia, and thrombocytopenia
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what are signs of the renal disorder?
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persistent proteinuria or RBC/WBC cellular casts, or 10 RBC/HPF
note if they are menstruating and urine must be sterile |
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what of the 5 lupus renal histologic types are the worst?
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diffuse proliferative glomerulonephritis and membranous nephritis
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any titer of this autoantibody indicates a significant risk for SLE renal disease.
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anit native DS DNA
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The other antibody associated with lupus is...
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anti Sm
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These auto antibodies are also found in lupus and can activate platelets resulting in thrombosis.
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anti phospholipid Ab's
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Aside from the expected vascular effects, antiphospholipid syndrome displays the following traits.
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recurrent fetal loss, false + RPR (syphylis), libman sachs endocarditis, livedo reticularis (red lines on hand)
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what are the characteristics of malar rash?
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fixed erythema, flat or raised, and it spares the nasolabial folds (known as the butterfly rash)
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what are characteristics of discoid rash?
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raised patches, adherent keratotic scaling, follicular plugging, and older lesions may cause scarring
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therapy for the serositis?
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NSAIDs, corticosteroids, immunosuppressives
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therapy for the arthritis?
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NSAID's, hydroxychloroquine, corticosteroids, immunosupprsseives
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therapy for blood dyscrasias?
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depends on severity, usually steroids and immunosuppresants
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therapy for renal?
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corticosteroids and immunosuppressives
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therapy for neurologic?
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symptomatic usually, corticosteroids and immunosuppressives
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therapy for rash?
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topical corticosteroids, systemic steroids, hydroxychloroquine, and immunosuppressives
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