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24 Cards in this Set

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  • Back
Lupus patients produce what kind of autoantibodies?
antinuclear antibodies
What are patient epidemiologic trends seen with lupus?
female>male
black>white
hispanics and chinese affected often.
low socioeconomic ppl affected
what gene abnormalities are associated?
deficiency in DR2, DR3, and C4A
what makes up for the discordance of identical twins with lupus?
exposure to secondary risk factors like infection, hormones, and UV radiation
what lesions are seen that you can biopsy?
vasculitis, vascular leukocclusion, and thrombosis from anti phospholipid antibody
What are the eleven traits that are possible with lupus (to be diagnosed you need to have four)?
serositis, oral ulcers, arthritis, photosensitive rash, blood dyscrasias, renal disorder, ANA, immunologic disorder, neurologic disorder, malar rash, discoid rash.
what trait distinguishes lupus oral ulcers from others?
they are painless
arthritis in lupus is clinically indistinguishable from what?
RA
Jaccoud's arthropathy seen in RA and lupus is do to what?
ligamentous laxity
what blood dyscrasias are seen?
hemolytic anemia with reticulocytosis (pt's are coomb;s positive, an Ab against RBC's), leukopenia, lymphopenia, and thrombocytopenia
what are signs of the renal disorder?
persistent proteinuria or RBC/WBC cellular casts, or 10 RBC/HPF
note if they are menstruating and urine must be sterile
what of the 5 lupus renal histologic types are the worst?
diffuse proliferative glomerulonephritis and membranous nephritis
any titer of this autoantibody indicates a significant risk for SLE renal disease.
anit native DS DNA
The other antibody associated with lupus is...
anti Sm
These auto antibodies are also found in lupus and can activate platelets resulting in thrombosis.
anti phospholipid Ab's
Aside from the expected vascular effects, antiphospholipid syndrome displays the following traits.
recurrent fetal loss, false + RPR (syphylis), libman sachs endocarditis, livedo reticularis (red lines on hand)
what are the characteristics of malar rash?
fixed erythema, flat or raised, and it spares the nasolabial folds (known as the butterfly rash)
what are characteristics of discoid rash?
raised patches, adherent keratotic scaling, follicular plugging, and older lesions may cause scarring
therapy for the serositis?
NSAIDs, corticosteroids, immunosuppressives
therapy for the arthritis?
NSAID's, hydroxychloroquine, corticosteroids, immunosupprsseives
therapy for blood dyscrasias?
depends on severity, usually steroids and immunosuppresants
therapy for renal?
corticosteroids and immunosuppressives
therapy for neurologic?
symptomatic usually, corticosteroids and immunosuppressives
therapy for rash?
topical corticosteroids, systemic steroids, hydroxychloroquine, and immunosuppressives