Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
Asthma Def
|
Reversible airway obstruction and Nonspecific bronchial hyper-reactivity
|
|
|
Asthma presentation
|
- common is cough, dyspnea, wheezing and chest tightness
- there can also be Allergic shiner or Atopic Dermatitis |
|
|
Asthma arterial blood gases
|
low PO2 (V/Q mismatch) and low PCO2
|
|
|
Intrinsic asthma
|
- (absence of atopy)
- No allergic or family hx – Usually adult onset following severe resp illness - Sx usually perennial - More refractory to treatment |
|
|
Extrinsic asthma
|
– Strong family hx w/ onset at a young age
– Other allergic problems – hx of specific allergic association triggers (pollen, animal dander) – correlation with skin and inhalation responses to specific antigens |
|
|
asthma histolgy
|
- edema and cellular infiltrates (esp. eos and lymphos)
- epi damage, hypertrophy and hyperplasia of SM layer, thickened BM, ↑ mucus secreting apparatus |
|
|
IgE in asthma
|
- Ag binds the IgE Ab and crosslinks it – this activates the mast cell
- it degranulates, releases bronchoconstricting and inflammation mediators (histamine and leukotrienes) - causes an increase in permeability, which give the Ag more exposure to IgE |
|
|
Asthma PFTs and B-agonist response
|
- reversible w/ B agonist
- PFT's show obstructive |
|
|
asthma inhalation challenge
|
- (methacholine) causes decrease in flow rates at concentrations that do not affect nonasthmatics
- correlates with severity of disease and Worsens with repeated allergen-induced “late phase” - COPD pts dont do well eihter, but do better than asthmatics |
|
|
asthma and DLCO
|
there is increased DLCO, which is weird, but useful for dx
|
|
|
Th1 phenotype
|
- will see presence of older sibling, early exposure to daycare
- TB, measles, or HepA - rural environment - after birth |
|
|
Th2 phenotype
|
- widespread use of Abs, western lifestyle, urban environment
- diet, sensitization or house-dust mites and cockroaches - in utero and assocated w/ IgE |
|
|
asthma and aspirin
|
when pts take aspirin, this shunts AA to the leukotriene pathway, which causes bronchoconstriction
|
