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24 Cards in this Set
- Front
- Back
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Latanoprost (Xalatan)
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PGF2a derivative
-drops for open angle glaucoma -for ocular HTN -SE: darkened iris at 6 or 12 months, sting, tear, burn |
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Main biological properties of LT
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1.increased vascular permeability
2.bronchoconstriction 3.chemotactic (leukotactic) |
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Name 7 effects of LTB4 who is a mediator in all types of inflammation.
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1,chemoattract nuetraphils
2.release lysosomal enzymes 3.release toxid O2 radicals 4.plasma exudation 5. promote nuetraphil adhesion 6.promote migration into cell 7.stimulate cytokine synthesis |
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Name 3 respiratory effects of LTC4 + LTD4 + LTE4
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1.bronchoconstriction
2.increased mucus production 3.mucosal edema |
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Name 6 cardiovascular effects of LTC4 + LTD4 + LTE4
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1.decrease contractitliy
2.decrease coronary blood flow 3.coronary artery constriction 4.decreased CO from 1,2,3 5. plasma exudation from postcapillary venuoles 6.vasodilates most vessels |
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Zafirlukast (Accolate)
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Zafirlukast (Accolate)
LT receptor antagonist -competes for LTD4 & LTE4 receptors -prophylaxis & tx of asthma -not for acute attacks |
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Montelukast (Singulair)
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LTD4 receptor antagonist
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Zileuton (Syflo Filmtab)
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5-LO inhibitor
-inhibits production of all LT -prophylaxis & chronic tx of asthma -SE: insomnia, agitation, anxiety, restless, irritiable |
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NSAID suppress the s/s of inflammation but do not stop the progression of inflammation
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true
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Main difference b/w NSAIDS are effectiveness.
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false, main difference is side effects, most have about the same efficacy
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Primary pharmacological mechanism of NSAIDS is to....
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inhibit cyclooxgenase activity
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What happens if you inhibit cyclooxgenase activity?
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block the synthesis of PGs, but remember now AA will go over to 5-LO pathway which produces LT
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Estimated annual cost of arthritis?
a,56,5 billion b.56.5 million c.82.5 billion d.82.5 million |
c.82.5 billion
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Arthritic diseases are
a.chronic, degenerative b.acute, painful c.acute, degenerative d. chronic, painless |
a. chronic, degenerative characterized by pain and loss of joint fx
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Main arthritis problem in U.S.?
a.rheumatoid arithritis b.osteoarthritis c.lower back arthritis d.knee arthritis |
b.osteoarthritis, 21 million
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Sx of osteoarthritis include..
a.pain, sometimes inflammation b.severe pain, joint paralysis c.profuse inflammation d.pain, scarring |
a.pain and sometimes inflammation
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First choice drug for osteoarthritis?
a.ibprofen b.naproxen c.indomethacin d.acetaminophen |
d.acetaminophen b/c tx mainly pain, doesn't tx inflammation
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Autoimmune disorder..
a.osteoarthritis b.rheumatoid arthritis c. MI d.small bowel obstruction |
b.rheumatoid arthritis
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4 cardinal signs of rheumatoid arthritis?
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redness due to
1.inflammation 2.heat 3.pain 4.swelling All r/t PG |
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In general NSAIDs are more active against COX1 than COX 2.
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true
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All but one NSAID involve irreversible inhibition of cyclooxygenase.
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false, all but one involve REVERSIBLE inhibition of cyclooxygenase; ASA causes irreversible inhibition
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NSAID therapuetic effects are mainly due to inhibition of COX 2.
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true
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NSAID side effects mostly due to inhibition of COX 2.
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false, cox 1
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COX 1/ COX 2 ratio is determined by dividing what?
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divide COX2 inhibition concentration (IC) by COX 1 IC
-low IC means you need less of drug to inhibit COX 2 -low ratio indicates COX 2 selectivity |
