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29 Cards in this Set

  • Front
  • Back
What do structures deep within the cerebral hemispheres and surrounding the hypothalamus control?
aspects of motivation, drives, emotions and memory
Limbic System: amygdala
receives sensory input from all the major senses
-especially smell

outputs project to many parts of brain including basal ganglia and cortex

stimulation of amygdala produces immediate increase in attentiveness
-followed by strong emotion, especially fear

destruction in animal produces decrease in aggression
(tame animal)
Limbic System: hippocampus
hippocampus and nearby cortical areas- critically important in short-term memory, especially the learning of facts
(as opposed to the acquiring of skills)

destruction leaves patients unable to form new memories of facts or events
-early memories are largely intact
-learned skills are largely intact (piano, tennis)
Long Term Potentiation (LTP) at spines of pyramidal cells in hippocampus
receptors are blocked by magnesium, even when glutamate binds it won't open unless you depolarize cell with enough activated AMPA receptors to drive Mg off.

Both AMPA (ligand gated) and NMDA are glutamate receptors
Mechanisms of LTP
strong and repeated depolarization of presynaptic membrane releases glutamate
-opens AMPA-type receptors
-produces strong depolarization of membrane of spine

Depolarization of spine membrane potential relieves Mg 2+ inhibition of NMDA-type glutamate receptors

Binding of glutamate to NMDA receptors causes opening
-Ca 2+ enters spine

Ca 2+ acts as second messenger to alter spine and produce long-term increases in efficacy of synaptic transmission

if you stimulate a pathway enough/repetitively = long term potentiation (LTP)
-causes learning so next time stimulus occurs you have a learned response
Thalamus
sensory input from every major sensory system comes into thalamus

output from thalamus is to sensory areas of cortex

These areas of cortex also send strong inputs back into thalamus

this cortical input and input from reticular formation acts as gates to regulate the sensory input
-some sensory input is allowed to enter cortex but other input is kept out
Somatosensory
"coming from your body"
What are the four lobes of the cortex?
frontal

temporal

parietal

occipital
motor cortex is directly connected to _____?
sensory areas
What is Wernicke's area near?
hearing and seeing area
What is Broca's area?
motor area

organzizing movements of tongue, throat, pharynx, lungs ect.

Speech production
Language area of the brain
Broca's area: speech
-a stroke in Broca's area results in difficulty speaking or even complete loss of speech
-does not affect understanding of speech or others or reading

Wernicke's area: comprehension
-a stroke in Wernicke's area can speak but words are out of sequence and often meaningless
-difficulty understanding spoken or written language

Both areas usually on left side of brain only
How do you speak a heard word?
1) hear

2) comprehension

3) organization of speech

4) motor to speak
How do you speak a written word?
1) see it

2)comprehension (Wernicke's area)

3)Broca's area (organize speech)

4)motor to speak
PET scanning (positron emission tomography)
Radioactive glucose emits a positron
-collides with electrons in the tissue to produce light (photons)

light intensity indicates amount of glucose taken up and is an indicator of the activity in the tissue

Glucose goes to cells that are active in brain, more action potentials
Cells of the brain are using what kinds of receptors?
Excitatory and Inhibitory Synaptic Receptors
Excitatory and inhibitory synapses are on?
the dendrites or cells body

inhibition decreases the size of the excitatory synaptic response
-reduces the probability of generation of an action potential
The cGMP gated channels are open or closed in darkness?
open, because the cGMP is high in the dark

the closing of the channels causes the membrane potential of the photoreceptor to hyperpolarize and decreases the release of transmitter
What types of cells have axons that go to the brain from the retina?
ganglion cells

photoreceptors act like TV camera (retina) and send signals to the brain (optic nerve)

Takes info from 100 million photoreceptors and integrates it to just 100 places
What are ganglions specific to?
location

tells the brain where the light is coming from
Partial decussation
the left cortex gets info from the right visual field in both eyes
Binocular vision
info 1st goes tot eh thalamus and then up to the cortex
Where is blindness produced?
Area 17, the primary visual cortex

lose perception
How do you record from a typical cell in the visual cortex?
stick electrode in visual cortex

stimulate a light in visual space and record response.

+/- is excitatory vs. inhibition
How much of the brain is used for vision?
1/4 to 1/3
T/F: There is a particular area of the brain that is specifically for recognizing faces?
True

it fires the "Face" cell in the inferotemporal cortex
Corpus Callosum
major bundle of 300 million axons connecting right and left hemispheres of cortex

bundle has been split in some patients to prevent epileptic seizures from spreading

"split brain" patients can be given tasks for only one side of the brain by presenting visual stimuli (including words) only to right or left visual field
What do axons communicate between?
the two sides of the brain
Split Brain Patients
words flashed in left visual field cannot be read; those in the right can

if picture of object is flashed in left visual field, patient can use left hand to pick object up (though denies having seen it)

in many patients some sorts of cognitive operations are more readily done in one hemisphere than in the other