Lorazepam (Valium)

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Lorazepam (valium)
Class MOA

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Class
Benzodiazepine; sedative; anticonvulsant.
Mechanism of Action
Anxiolytic, anticonvulsant and sedative effects; suppresses propagation of seizure
activity produced by foci in cortex, thalamus and limbic areas.

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Lorazepam (valium)
Indications

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Indications
Initial control of status epilepticus or severe recurrent seizures.
Severe anxiety.
Sedation.

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Lorazepam (valium)
Contraindications

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Contraindications
Acute narrow-angle glaucoma.
Coma, shock or suspected drug abuse

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Lorazepam (valium)
Adverse reactions

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Adverse Reactions
Respiratory depression, apnea, drowsiness, sedation, ataxia, psychomotor impairment,
confusion.
Restlessness, delirium.
Hypotension, bradycardia.

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Lorazepam (valium)
Drug Interactions

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Drug Interactions
May precipitate CNS depression if patient is already taking CNS depressant
medications.

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Lorazepam (valium)
how supplied

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How Supplied
2 and 4 mg / ml concentrations in 1 ml vials.

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Lorazepam (valium)
Dose and administration

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Dosage and Administration
Note: When given IV or IO, must dilute with equal volume of sterile water or
sterile saline; When given IM, Lorazepam is not to be diluted.
Adult: 2-4 mg slow IV at 2 mg / min. or IM; may repeat in 15-20 minutes to
maximum dose of 8 mg. For sedation: 0.05 mg / kg up to 4 mg IM.
Pediatric: 0.05 - 0.20 mg / kg slow IV, IO slowly over 2 minutes or IM; may repeat
in 15-20 minutes to maximum dose of 0.2 mg / kg.

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Lorazepam (valium)
DOA

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Duration
Onset of action: 1-5 minutes.
Peak effect: variable.
Duration of action: 6-8 hours.

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Lorazepam (valium)
Specials

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Special Considerations
Pregnancy safety: Category D.
Monitor BP and respiratory rate during administration.
Have advanced airway equipment readily available.
Inadvertent arterial injection may result in vasospasm and gangrene.
Lorazepam expires in 6 weeks if not refrigerated.