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4 Cards in this Set
- Front
- Back
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Define long term potentiation:
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Long-lasting
Strengthening of the response of postsynaptic nerve cell to stimulation across the synapse Occurs with repeated stimulation. |
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How is the NMDA receptor involved in LTP?
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Binding of glutamat to the NMDA receptor triggers the opening of a channel which is permeable to monovalent cations (Na+ and K+) generating depolarisation
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What receptor is altered during long term potentiation?
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AMPA is phosphorylated increasing single channel permeability
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What is the roleof Calcium-calmodulin-dependent-proteinkinase II (CaMKII) in generation of LTP?
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CaMKII phosphorylates AMPA receptors.
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