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10 Cards in this Set
- Front
- Back
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Which receptor state do LAs have the highest affinity for?
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Open or inactive (not resting)
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What causes CNS and CV toxicity?
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Stabaliztion of excitable tissue/afferent neurons
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What potentiates LA toxicity? Why?
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Increased PaCO2, d/t increased cerebral blood flow and decreased pH -> decreasssed protein binding
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What are symptoms of LA CNS toxicity?
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Circumoral cyanosis, lightheadedness, tinnitus, visual disturbances, slurring of speech, muscle twitching, irrational conversation, unconsciousness, grand mal seizure, coma, and apnea.
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Describe the progression of CNS symtptoms and their mechanism
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Blockade of inhibitor pathways in the cerebral cortex -> exication, and later depression of CNS
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What potentiates CNS toxicity?
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Potency, speed of increase in systemic LA levels, acidosis
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What are the direct effects of LAs on cardiac muscle?
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decreased contractility, automaticity (minimal), rhythmaticity, conductivity, inotropy
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Which is more resistant to toxicity, CV or CNS?
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CV
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What dose of LA is neccessary to produce CV toxicity relative to CNS toxicity?
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3x
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What potentials LA-induced negative inotropy?
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Acidosis, hypercapnia, hypoxia
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