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10 Cards in this Set
- Front
- Back
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What is the significance of nodes of ranvier for LAs?
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Limited diffusion barrier, and thus may be the primary sites where LAs exert their action
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What is salatory conduction?
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Electrical impulse jumps from node to node, significantly facilitating conduction speed along axon
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What is the neuronal membrane composed of?
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Phospholipids, other lipids, cholesterol, proteins and carbs (carbs usually conjugated to proteins/lipids)
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What is the mass of proteins in nonmyelinated nerves?
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1/3 of total mass, most at the membrane surface
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Describe nerve lipids
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Ordered, behave as fluid components within membrane interior
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What does it mean when we say membrane phospholipids are fluid?
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The phospholipid fatty acyl groups rotalate, tumble and flex
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Where does the most motion within the lipid membrane take place? Why?
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At the ineriro because the phospholipid tails are most fluid and have the least orientation near the center of the hydrocarbon region
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What is the role of cholesterol in the lipid membrane?
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Interdigitated among lipids, influences behavior favoring parellel ording of fatty acid chains, reduces rotation/maintains order
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What do the dynamics of lipids affect re: LAs?
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Membrane partitioning, permeability of LA, LA access and orientation to target proteins within membrane
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What electical function do cell membranes have?
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They are capacitors, electical insulations between two conduction inonic solutions -> storage of energy
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