Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
esters
|
cocaine, procaine, and benzocaine; hydrolyzed by hepatic and plasma esterases
|
|
|
amides
|
lidocaine and bupivicaine; hydrolyzed in the liver
|
|
|
especially cardiotoxic
|
bupivicaine
|
|
|
only LA that is not basic amine
|
benzocaine- therefore not water soluble
|
|
|
LA MOA
|
block NA+ channel from the intracellular side
|
|
|
axons most susceptible to LAs
|
smallest, those that conduct high frequency signals, and those that transmit pain sensation
|
|
|
LA toxicities
|
produce arrhythmias, coma, and convulsions
|
|
|
why give vasoconstrictors with LAs
|
reduce blood flow and prolong duration of action
|
|
|
ester metabolites
|
may cause allergic reaction in some subjects manifested upon reexposure
|
|
|
cocaine actions
|
LA, sympathomimetic- HTN, tachy, and arrhythmia, and intense euphoria
|
|
|
saxitoxin and tedrodotoxin
|
toxins that act on sodium channels
|
