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Local Anesthetics

by tamiehunt13, Sep. 2011

Subjects: anesthetics local

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	Lidocaine	Amide: Hepatic metabolism stabilizes ventricular dysrhythmias suppress trach tube cough spinal/epidural blocks
	Mepivacaine	Amide : Hepatic metabolism Only parentally administered drug approved by FDA for horses Equine limb blocks
	Bupivacaine	Amide: Hepatic metabolism SE: ventricular tach/fib nerve blocks, intrapleural, spinal, intrathecal techniques
	Benzocaine	Aminoester : plasma esterase metabolism Topical absoprtion:cough drop, Produces PABA
	Proparacaine	Aminoester: plasma esterase metabolism Ophthalmology: corneal irritation
	Local Anesthetic Amides	Lidocaine Mepivicaine Bupivacaine
	Local Anestetic Aminoesters	Benzocaine Proparacaine
	Which local anesthetics should you use on a patient with liver disease	Aminoesters, no liver metabolism Benzocaine and Propraracaine
	Local Anesthetics act by	blocking Na channels so decreased permeability prevents excitation.
	Local Anesthetic toxicity	CNS at low concentrations - Generalized descending CNS depression CVS at high concentrations - hypotension/dysrhythmias