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5 Cards in this Set
- Front
- Back
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What do unfractionated heparins bind?
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Binds to both thrombin and antithrombin III.
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What do unfractionated heparins prevent?
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Factors IX-XII
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How are low molecular heparins different from unfractionated heparins?
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They cannot bind simultaneously to both thrombin and antithrombin III. Therefore, they do not prevent thrombin.
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How do LMWH's work specifically?
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They inhibit factor Xa, preventing thrombus formation, but not interfering with clotting times.
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How does the 1/2 life of LMWH's vary from unfractionated?
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LMWH's don't bind to macrophages and get cleared by the liver, so thier 1/2 life is 2-4 times longer.
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