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5 Cards in this Set

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What do unfractionated heparins bind?
Binds to both thrombin and antithrombin III.
What do unfractionated heparins prevent?
Factors IX-XII
How are low molecular heparins different from unfractionated heparins?
They cannot bind simultaneously to both thrombin and antithrombin III. Therefore, they do not prevent thrombin.
How do LMWH's work specifically?
They inhibit factor Xa, preventing thrombus formation, but not interfering with clotting times.
How does the 1/2 life of LMWH's vary from unfractionated?
LMWH's don't bind to macrophages and get cleared by the liver, so thier 1/2 life is 2-4 times longer.