Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
a1 receptor
|
decreases mucosal secretion via constriction
vasoconstriction of arterioles (a1 and B2 R here but a1 predominates)=increases TPR and diastolic BP contracts veins contracts GI and bladder sphincter contracts radial dilator muscle and dilates the pupil = MYDRIASIS Gq=increase IP3/DAG=increases Ca and activates PKC |
|
|
NE and phenylephrine are prototypic ________
|
a1 agonists
|
|
|
phenoxybenzamine
phentolamine prazosoine all are prototypic _______ |
a1 antagonists
|
|
|
a2 receptor actions
|
acts at vasomotor ganglion to decreases sympathetic outflow -- blocks ACH release from preganglionic sympathetics
decreases insulin and thus lipolysis (B cells of Pancreas) Gi=decreases cAMP by inhibiting AC and thus K+ conductance increases and PKA activity decrease |
|
|
prototypic a2 agonists and antagonist
|
agonist=clonidine
antag=yohimbine |
|
|
B1 receptor
|
Heart:
SA Node = increased HR ATria=increased contractility AV node=increases conduction velocity and automaticity when acting as a pacemaker, otherwise suppressed by SA ventricles=increased contractility kidney=acts on JG cells and increases renin release B1=Gs=increased cAMP via AC activation and activates PKA --remember caMP activates HSL which breaks down TGs (lipolysis) -- think glucagon (during fasting, increases cAMP to phosphorylate enzymes and increase Glc levels in blood) |
|
|
B2 receptor
|
coronary artery vasodilation
vasodilation of skeletal muscle arteries (remember a1 dominates so if symp response=constriction here) relaxation of bladder wall bronchodilatoin Its Better 2 relax (lungs, vessels, bladder). Gs=increased cAMP (think glucagon action) wildcard: increases insulin release |
|
|
low doses of Epi are selective for ___ receptor
|
B2
|
|
|
give the system/receptor:
pupil dilation (radial dilator constriction) pupil constriction (pupillary sphincter muscle constriction) far vision (relax ciliary m) near vision (constrict ciliary m) |
pupil dilation = symp/a1
pupil constriction=parasym/M3 far vision=symp/B near vision=parsym/M3 |
|
|
M1 receptor action
|
increases gastric secretion from parietal cells
CNS/PNS effects |
|
|
M2
|
decreases heart rate and contractility of the atria
Gi receptor==decreased cAMP and increased K+ conductance |
|
|
M3
|
Gq=increased IP3 and Dag and increased Ca into cell
increases smooth muscle contraction: -GI walls and sphincters (digestion/defacation/peristalsis -GU=bladder constriction and sphincter relaxation to facilitate urination -increases sweat and gastric acid release and tears -dilation of vascular endothelium via release of NO to lower bP bronchoconstriction==increases work of breathing (smooth bronchial muscle) + increases bronchial secretions contracts uterus in PG women contracts the pupil/sphincter muscle=miosis contraction of ciliary muscle for near vision/accomodation |
|
|
type of receptor is M1
|
Gq=increases IP3/DAG and increase PKc actiivy and increases Ca into cell
|
|
|
D1 receptor
|
Gs=increased camp
relaxes renal vascular smooth msucle |
|
|
M2 effects on the heart
|
SA=decreased HR
Atria=decreased contractility AV=decreased conductoin velocity and decreased automaticyt (only if AV is pacemaking) Ventricles=sligh decreased contraction |
