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5 Cards in this Set
- Front
- Back
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Causes liver cirrhosis? (8)
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Anything which damages hepatocytes can cause liver cirrhosis - as damaged hepatocytes activate Kuppfer cells to lay down collagen leading to fibrosis and sclerosis:
Viral hepatitis (B+C chronic) Autoimmune hepatitis Alcohol Primary sclerosing cholangitis Primary Biliary sclerosis Wilsons - Cu metabolism (causes hepatocyte damage) Cystic fibrosis Alpha 1 antitryspin deficiency |
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What is Primary sclerosing cholangitis?
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Cholestatic liver disease - inflammation and fibrosis of intra and extra hepatic bile ducts
Predominantly affects young men Link IBD (esp UC) Test: P-ANCA |
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What is Primary Biliary cirrhosis (PBC)
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Chronic prgressive disorder middle aged women.
Granulomatous inflam. portal tracts leading to loss of small and medium bile ducts. Strong link thyroid disease Eventual cholestasis |
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Tests PBC (4)
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LFTs
US scan - no sign biliary obstruct Antinuclear antibodies (present 15%) Antimitochondrial antibodies (present 95%) |
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Symptoms PBC?(8)
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Pruritis
Jaundice Abdo discomfort Fever + rigors Hepato-splenomegaly Xanthoma Osteoporosis + fractures Dysthyroid symptoms |
