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29 Cards in this Set
- Front
- Back
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aminolevulinic acid precursors
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Glycine and Succinyl coenzyme A
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Protoporphyrin IX
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is the final stage before iron celestation and Heme formation
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Watson-Schwartz
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test that can help diagnose Porphyrias
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Coproporphyrin
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will turn orange-red in acid. Like copper
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Sample for porpharia test
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refridge, 24 hour urine, sheilded form light (brown bottle)
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Biliveridin is the precuror
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to bilirubin formation
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Diazotized sulfanilic acid
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complexes with bilirubin to make Azobilirubin
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Uridine diphosphate glucuronyltransferase
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Enzyme that conjugates bilirubin
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Urobilin
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micro organisms breakdown bilirubin in the gut to make...
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kernicterus
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accumulation of bilirubin in the brain
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urobiligen is reabsorbed
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through the intestine |
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Bilirubin fraction that covalently bonds to albumin
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Delta fraction
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Spleen
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Where RBCs disintigrate. Heme -> bilirubin
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Methods that quantify bilirubin
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Bilirubinometer, Jendrassik and Grof, Bilirubin oxidase
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direct bilirubin
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conjugated in liver, with glucuronic acid, excreted in urine in jaundiced patients
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Diazo
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sulfanilic acid, hydrochloric acid, sodium nitrite
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Indirect bilirubin quantified by rxn with
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caffeine-sodium benzoate
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Bilirubin oxidase
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oxidized to bolorless biliverdin
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Urobilinogen is a group
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Urobilinogen, strecobilinogen, urobilinogen
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Obstructive jaundice
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increased conjugated bili in serum. it's got no place to go
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hemolytic jaundice
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unconjugated bili incresed
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Neonatal jaundice of the hepatic type
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def in conj enzyme
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obstruction of bile duct
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bili in urine, no urobili in stool or urine, pale stool
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Viral hepatitis, indicator
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elevation of in serum unconjugated bili
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Crigler-Najjar syndrome
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def. of enzymes that conjugate bilirubin
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Gilbert syndrome
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inability to transport bilirubin past hepatic membrane. no make it to liver for the conj.
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Dubin Johnson syndrome
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Impaired excretion of bilirubin into the bile, hepatic uptake of bilirubin is normal, increased levels of bili in urine
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Hepatic jaundice:
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Cirrhosis, Crigler-Najjar syndrome, Hepatitis
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Acute hemolytic anemia
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prehepatic jaundice
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