Listeria And Erysipelothrix

Front 1

Listeria Genrally

Back 1

Compromised host CMI important in disease development.

L. monocytogenes principal pathogen.

Front 2

Listeria:
Pathogenic Features and Virulence

Back 2

Internalin: bacterial surface protein that attaches to epithelial host cell E-cadherin and induces phagocytosis

Facultative intracellular parasite of epithelial cells, liver cells, macrophages, neural cells, and trophoblast cells.

listeriolysin O, (LLO), a hemolysin which is major virulence factor

LLO also assists in escape from secondary spreading vacuoles by lysis of outer membrane of double vacuole.

Front 3

Listeria:
Transmission

Back 3

Ingestion – primary route.
Inhalation possible

Exposure via ingestion is common but disease is rare. Disease more common in immunocompromised host

to central nervous system (CNS)

Front 4

Listeriosis:
Clincial Disease

Back 4

Neural or CNS form – “circling disease”; “silage disease”.

Abortions

Occasionally mastitis

Meningoencephalitis

Symptoms include fever, propulsive walking, head tilt, nystagmus, head pressing, various cranial nerve deficits

Histopathology –microabsecess in CNS

Front 5

Listeriosis:
Clincial Disease (humans)

Back 5

abortions, septicemia, encephalitis. Infection acquired by consuming contaminated foodstuffs.

-****Heat tolerant – survives pasteurization

Front 6

Listeriosis:
Diagnosis

Back 6

isolation of organism from blood or infected brain or abortive tissues.

Selective enrichment media

Front 7

Listerirosis:
Treatment

Back 7

100% fatality if untreated.

Anitbiotics

Front 8

Erysipelothrix (Generally)

Back 8

Gram positive rod