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10 Cards in this Set

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  • Back
What is adherence?
Interaction of a host cell's surface receptor (carb residue) and a bacterial adhesin, surface structure, often a pili.
What is adhesin diversity?
The wide range of forms of bacterial adhesions that are required to survive in different environments. Each adhesin binds to a different class of host cell receptors
How are adhesins used to escape from immune system?
Since they are differentially expressed that can escape from immune responses
How does antigenic variation in bacteria occur through pili?
Each bacteria possesses genetic information for a large number of varient pilin proteins.
Why will there never be a vaccine for Nissera gonerria?
Because that bacterium does not change the type of pili it expresses (so it can be targeted with pharm), instead it changes the components of the origingal pili to evade death.
Compare the two types of pilin genes?
1. pilE - expressed genes
2. pilS - silent cassette that is introduced into intactg pilE but is promoterless and incomplete
What happens when a pilS cassette is introduced into a pilE?
New pilis of different antigenicity are made from the pilS now that pilE is there to help.

Between pilS and pilE, which are required for antigenicity of the pilli?
How can silent cassettes come into to a gonococci?
Via transformation (uptake from outside) since pilS's are exogenotes and gonococci is naturally competent for DNA transformation.
Other than transformation, how does gonococci interact with its environment?
Gonococci possess a DNA cannon, a Type IV secretory apparatus which secretes DNA into the environment. This secretory device is the major source of DNA FOR transformation.