Lisa Endo 1

Front 1

whats growth velocity of babies in 1 yr?
-when do they double wt? triple ?

Back 1

Wt: double by 4 mo; triple by 1 yr ( avg 1 yo = 10 kg )
HT: * rule of 24:
1st yr: 24-25 cm/yr; 1 x 24
-2nd yr: is 12 cm/yr: 2 x 12
-3rd yr: 8 cm/yr: 3 x 8

Front 2

How many cm does child grow > 4 yo?
-when should you worry: if they are not growing ? how many cm/ yr; what's abnl?

Back 2

- grow 5 cm/yr > 4 yo **** (2 inches/yr)
-**( if growing < 5 cm or 2 inc/yr; abnlr); ** check bone age of hand/wrist

Front 3

during puberty, what's growth velocity;
whats conversion cm to inches?

Back 3

during puberty: grow 9-10 cm/hr; (if given Inches: multiply 2.5 to get cm); girls will have 1-2 inches left once they reach menarche

Front 4

when do you need to eval child for short stature?

Back 4

-need eval: if Ht < 3% or Percentiles are being crossed (but it’s ok in 1st 2 years of life; > 2 yr, not okay to cross %)

Front 5

How calculate ht for little boy vs girl?

Back 5

-Males: (mother ht + 5 in + Dad ht) /2 [ or 13 cm
-MPH: girls: dad ht – 5 in + Moth ht )/2

Front 6

delayed bone age, reaches goal ht
-late bloomer; + FH of late bloomer; NL growth rate!!
? dx?

Back 6

Constitutional growth delay

Front 7

-most common cz;
-Nl bone age
- may be cz by genes:

Back 7

Familial Short Stature

Front 8

h/o cranial insult/tumor
-growth slows > 6 mo

Back 8

GH defeciency

Front 9

Hypothyroidism; Cushings

Back 9

Chronic Inflamm/Illness;
-Malabsorptin

Front 10

when is GH used for treatment ? and side effects?

Back 10

GH def, chronic renal insuff, turner, prader willi, SGA w/o cathcup, iodiopathic short stature, noonan;
* SE: - side effects: head, shoulders, knees, n HIPS: benign intracranial HTN (pseudotumor cerbri), scoliosis, SCFE, ~ thyroid, cortisol deficiences, inc risk of colon CA)

Front 11

list syndromic causes of short stature

Back 11

Trisomy 21
Turner; noonoan; prader willi, pseudo-hypoparathyroid (albrights); russel silver

Front 12

variants: short, edema @ birth, ovarian deficits, low hairline, webbed neck, abnl carrying angle, shield chest,
horseshoe defect
-absent pubertal development/infertility
*dx and what heart defects?

Back 12

-L sided heart defects (bicuspid AV or coarc);
-Turner: girls only
-45 XO (abnl X or Y),

Front 13

PTPN11 gene defect: boys & girls; short, low hairline, shield chest, no renal defects, infrequent infertility
*dx adn what heart defects?

Back 13

noonan; R heart defects: pulm stenosis

Front 14

short, dev delay, morbid obesity, hyperphagia;
-almond shaped eyes;
-hypogonadotropic hypogonadism: small phallus, small testicles
* dx and cause?

Back 14

rader willi; 15 q ll

Front 15

small at birth, limb assymtery; triangular head/big fontanelle; cryptorchidms, no catch up growth (born small/stay small): no catchup by 2

Back 15

Russell silver (IUGR/SG)

Front 16

what's genetics of klinefelters?

Back 16

47XXY

Front 17

causes of tall stature?

Back 17

Marfan – hyperexensible ;
Homocystinuria: low lens; hyperthyroidism; GH excess (gigantism) –rare;
-precocious puberty but tall stature→ short adult height); soto syndrome (cerebral gigantism) : bad MR

Front 18

order of girl puberty?

Back 18

: TAGME:
-thelarche: 8-13
-Adrenarche: pubic hair (9-13)
-Growth spurt: pks @ Tanner 2-3
-Menarche ~ 2 yrs after puberty; ~ 12.4 yrs

Front 19

male order of puberty

Back 19

THPGA
-testicular enlargement
---4 cc – Tanner 2
-pubic Hair: 6 mo – 1 yr later
-Penile enlargement
-Growth spurt: T 3-4
-Axillary Hair (14 yo)

Front 20

list causes of peripheral precocious puberty; what's Lh, FSH, testosterone?
-gonadotropin independent PP: boys only

Back 20

-low LH, FSh, hi testosterone;
1) Familial Male

Front 21

G protein abnl: café- au lait, Fibrous Dyspalsia, Preciocious puberty

Back 21

McCune Albright

Front 22

nL ht pre-adolescence
-no growth spurt
-may have adrenarche
-delayed puberty; what's causes

Back 22

Hypogonadotropic hypogonadism
-if ~ anosomia = Kallman!!

Front 23

-septo-optic dysplasia
-empty sella syndrome
-CNS tumors: cranio
with delayed puberty are ~ with what?

Back 23

) Congenital Panhypopituatarism:

Front 24

Hypergonadotropic hypogonadism:

Back 24

- mumps/orchitis; -turner, ovarian failure
-psuedohermaphrodistism: **klinefelter
- 47 XXY; 1:500; tall, eunucoid proportions; gynecomastia; stalled puberty: tanner 3-4; testicles noted to be small:

Front 25

2 wk M w FTT, persistent vomiting, dehydrations, acidosis

Back 25

CAH 21 OH def

Front 26

Inguinal hernia, primary amenorrhea, no pubic hair

Back 26

Androgen Insensitivty Syndrome

Front 27

11 yo F w/ ambiguous genitalia, masculinzes at puberty

Back 27

5 alpha reductase def

Front 28

3 day old baby, 10 lb @ birth, jittery

Back 28

Infant DM mom w /hypocalcemia

Front 29

5 day old small jaw broad nose,

Back 29

TOF, sz DiGeorge,/VCF

Front 30

8 yo w/ dev deloay, short round facies, SQ calicficx, short 4 th digit, hypocalcemia

Back 30

Albrights heridtary Osteodystrophy/pseudohypoparathyroidism