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9 Cards in this Set
- Front
- Back
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apolipoprotein A-I
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Activates LCAT
esterifies cholesterol, trapping it in HDL used for formation of new HDL (all A's) |
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apolipoprotein B-100
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Binds to LDL receptor
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apolipoprotein C-II
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Cofactor for lipoprotein lipase
found on VLDL, LDL -- HDL is circulating reservoir |
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apolipoprotein E
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Mediates remnant (extra) uptake
(chylomicron) |
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apolipoprotein B-48
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mediates chylomicron secretion
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chylomicron
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delivers (dietary) TG to peripheral tissue and (dietary) cholesterol to liver
secreted by intestinal epithelium EXCESS: pancreatitis, lipemia retinalis, eruptive xanthomas B-48, A, C-II, E |
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VLDL
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delivers hepatic TG to tissues
secreted by liver EXCESS: pancreatitis B-100, C-II, E |
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LDL
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delivers hepatic cholesterol to tissues
taken up in tissue by receptor-mediated endocytosis EXCESS: atherosclerosis, xanthomas, arcus cornae B-100 |
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HDL
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reverse cholesterol transport (tissues to liver)
repository for apoE and apoC (VLDL and chylomicron metab) Secreted from liver and intestine A-I, LCAT, CETP (transfer of cholesterol esters to other lipoprotein particles) |
