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21 Cards in this Set
- Front
- Back
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Composition of VLDL
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B-100 - contains B-48 domain
C-II contains activation of lipoprotein lipase E- RME |
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Composition of LDL
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B-100- B-48 domain
high cholesterol |
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excess cholesterol
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not needed
esterified ACAT acyl Coa- cholesterolacyltransferase |
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metabolization of LDL
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LDL receptors on liver recognize the apoprotein B-100 and do RME
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metabolism of LDL in liver
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bile salt synthesis
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other function of metabolism of LDL
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steroid hormone synthesis
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where does steroid hormone synthesis occur
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in the ovaries, testes, and endocrine tissues
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purposes of LDL cholesterol
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1) downregulates HMG CoA reducatase, rate limiting step of cholesterol synthesis
inhibits de novo synthesis of cholesterol 2)down regulates LDL receptor synthesis decrease LDL uptake |
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HDL is synthesized where
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in the liver, "good cholesterol"
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Function
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1) exchanged of apoliprotiens between lipids and lipoprotein particles
2) used in reverse-cholesterol transport |
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composition of HDL
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low TAG
moderate Cholesterol protein high Apoproteins A-1 which activates LCAT C-II sent to chyliomicron and VLDL E helps in RME |
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what does LCAT stand for
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Letchin cholesterol acyltransferase
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LCAT purpose
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mediates the uptake of free cholesterol from peripheral tissues
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conformational change of nascent HDL to LDL
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discoid to spherical
addition of esterified esters into the center of the molecules |
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HDL and VLDL
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cholesterol ester tranfer protein mediates the exchange of cholesterol ester of HDL for TAG from VLDL forming LDL
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dietary significance of HDL and VLDL association
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increase LDL forms decrease HDL good cholesterol
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return of cholesterol ester
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returned via receptor mediated endocytosis of HDL in liver
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regulation of HDL
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1) increased by estrogen, excercise and red-wine
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do women or men have higher levels of HDL
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women
estrogen increases the amount of HDL |
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mechanism of red-wine
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increases the synthesis of ApoproteinA- 1
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where is VLDL synthesized
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in the liver (mainly)
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