Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Chylomicrons:
- major apolipoproteins - origin - function |
- A, B48, C
- intestine - transport triglycerides, which are hydrolyzed by LpL (via apoC) into FFAs and glycerol |
|
|
VLDL
- major apolipoproteins - origin - function |
- B100, C, E
- liver - transport of liver triglycerides, which are hydrolyzed by LpL (via apoC) --> converted to IDL --> LDL |
|
|
IDL
- major apolipoproteins - origin - function |
- B100, C, E
- periphery, VLDL (via LpL) - LDL precursor |
|
|
LDL
- major apolipoproteins - origin - function |
- B100
- periphery, VLDL (via LpL) - cholesterol transport from liver to extrahepatic tissues (which recognize B100) --> receptor-mediated endocytosis in cells, exchanges cholesterol esters or proteins with HDL |
|
|
HDL
- major apolipoproteins - origin - function |
- A, C
- liver, intestine - cholesterol removal from tissues via ABCA1, transferred to other lipoproteins and to the liver; relies on LCAT for esterification of cholesterol |
|
|
Function of ApoA1?
|
activates LCAT
|
|
|
Function of ApoB?
|
metabolism of chylomicrons, VLDL, LDL
hepatic and peripheral tissue uptake of LDL B48 - chylomicron uptake |
|
|
Function of ApoCII?
|
component of HDL, activates LpL
|
|
|
Function of ApoD?
|
component of HDL
|
|
|
Function of ApoE?
|
receptor recognition of IDL and chylomicron remnants by the liver
|
|
|
Increased chylomicrons
Eruptive xanthomas Hepatosplenomegaly Pancreatitis Autosomal recessive |
LpL deficiency
|
|
|
Increased chylomicrons
Eruptive xanthomas Hepatosplenomegaly Autosomal recessive |
Familial ApoC deficiency
|
|
|
Increased VLDL remnants
Pancreatitis Autosomal recessive |
Familial hepatic lipase deficiency
|
|
|
Increased chylomicrons
Increased VLDL remnants Palmar and tuberoeruptive xanthomas CVD and PVD Autosomal recessive or dominant |
Familial dysbetalipoproteinemia
(apoE deficiency) |
|
|
Increased LDL
Tendon xanthomas CVD Autosomal dominant |
Familial hypercholesterolemia
(LDLr defect) OR Familial defective apoB-100 |
|
|
Increased LDL
Tendon xanthomas CVD Autosomal recessive |
Autosomal recessive hypercholesterolemia (ARH gene defect)
OR Sitosterolemia (ABG5/8) - inability to effluex sterols |
|
|
Decreased LDL
Fat malabsorption Spinocerebellar degeneration Retinopathy Autosomal recessive |
Abetalipoproteinemia (MTP gene defect)
|
|
|
Decreased LDL
Fat malabsorption Spinocerebellar degeneration Retinopathy Autosomal dominant |
Hypobetalipoproteinemia (ApoB defect)
|
|
|
Decreased HDL
Hepatosplenomegaly Orange tonsils CVD Autosomal dominant |
Tangier disease (ABCA1 defect)
|
