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43 Cards in this Set

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the major lipids of the body
triglycerides, cholesterol, phospholipids, and glycolipids
the source of triglycerides in the body can either be exogenous( ) or endogenous ( )
dietary or primarily hepatic (liver)
( ) and ( ) promote triglyceride breakdown when the cells need energy and glucose stores have been depleted
Epinephrine and cortisol
( ) is used for the manufacture and repair of cell membrane, for synthesis of bile acids and vitamin D, and is the precursor of five major classes of steroid hormones
Cholesterol
normal cholesterol
140-200 mg/dL
---- and ---- are used to measure fetal lung maturity
Lecithins and Sphingomyelin
The four major classes of lipoproteins separaTED BY ULTRACENTRIFUGATION ARE
CHYLOMICRONS, VLDL, LDL, AND HDL
----- ARE THE LARGEST LIPOPROTEINS PARTICLES WITH DIAMETERS RANGING FORM 80 NM-1200 NM. THEY ARE THE MAJOR CARRIERS OF EXOGENOUS TRIGLYCERIDES
CHYLOMICRONS
MAJOR STUCTURAL PROTEIN IN HDL
APO A-1
MAJOR STRUCTURAL PROTEIN IN VLDL AND LDL
APO B-100
A CREAMY LAYER RISING TO THE TOP OF A FASTING SERUM SPECIMEN THAT HAS BEEN COOLED OVERNIGHT INDICATES THE PRESENCE OF CHYLOMICRONS & SIGNALS A DEFECT IN THEIR CLEARANCE
STANDING PLASMA TEST
MAJOR CARRIERS OF ENDOGENOUS(LIVER) TRIGLYCERIDES
VLDL
EXCESS DIETARY INTAKE OF CARBS ENHANCES HEPATIC SYNTHESIS OF TRIGLYCERIDES, WHICH IN TURN INCREASES
---- PRODUCTION
VLDL
--- TAKES EXCESS CHOLESTEROL FROM THE TISSUES & RETURN IT TO THE LIVER (REVERSE TRANSPORT)
HDL
CARRIES CHOLESTEROL TO THE TISSUES
LDL
THE CURRENT REFERENCE METHOD FOR CHOLESTEROL USES ------ EXTRACTION AFTER HYDROLYSIS W/ ALCOHOLIC --- FOLLOWED BY REACTION WITH ---------- -------- COLOR REAGENT
HEXANE KOH


LIEBERMANN-BURCHARD
MEASUREMENT OF TRIGLYCERIDES IN CONJUNCTION W/ CHOLESTEROL IS USEFUL IN DETECTING CERTAIN GENETIC AND OTHER
--------- ---------
METABOLIC DISORDERS
FETAL LUNG MATURITY HAS BEEN EVALUATED FROM CHAR. PATTERNS OF ------------ IN AMNIOTIC FLUID
PHOSPHOLIPIDS
------- GEL HAS BEEN THE MOST COOMON MEDIUM FOR SEPARATION OF INTACT LIPOPROTEINS
AGAROSE
--( ) CAN BE MEASURED AS AN INDEPENDENT INDICATOR OF --- RISK
CHD
-------------- GEL IS THE MEDIA USED FOR SEPARATION OF LIPOPROTEIN
POLYACRYLAMIDE
SEPARATION METHODS INVOLVING CHEMICAL PRECIPITATION, PRECIPITATES OUT ---- & --- TO MEASURE ---
VLDL& LDL HDL
THE NCEP GUIDELINES NOW INCLUDE --- CHOLESTEROL IN THE FIRST MEDICAL WORKUP
HDL
THE EARLIEST COMMON PRECIPITATION METHOD USED ------- IN COMBO W/ --------- TO PRECIPITATE THE APO B- CONTAINING LIPOPROTEINS
HEPARIN MANGANESE
THE CURRENT CHEMICALS USED TO PRECIPITATE OUT APO B- CONTAINING LIPO. IS ------- -------
DEXTRAN SULFATE
A SIGNIFICANT PROBLEM WITH HDL PRECIPITATION METHODS IS INTERFERENCE FROM ELEVATED ------------ LEVELS, WHICH PREVENTS SEDIMENTATION OF THE PRECIPITATE.
TRIGLYCERIDE
WHEN THE TRIGLYCERIDE RICH VLDL & CHYLOMICRONS ARE PRESENT, THE LOW DENSITY OF LIPOPROTEINS MAY PREVENT THEM FROM ----------- OR MAY EVEN CAUSE -------- DURING CENTRIFUGATION
SEDIMENTATING FLOATING
THE PROVEN ATHEROGENIC LIPOPROTEIN IS THE PRIMARY BASIS FOR TREATMENT DECISIONS IN THE NCEP CLINICAL GUIDELINES IS --- -----------
LDL CHOLESTEROL
GOOD CHOLESTEROL
HDL
BAD CHOLESTEROL
LDL
A SIMPLER TECHNIQUE FOR LDL CHOLESTEROL QUANTITATION THAT IS COMMON IN BOTH ROUTINE AND RESEARCH LAB. & THAT BYPASSES ULTRACENTRIFUGATION IS THE SO CALLED ---------- ----------- OR DERIVED BETA-QUANTIFICATION
FRIEDEWALD CALCULATION
HIGHER VALUES OF FAT IN STOOL AND URINE CAN INDICATE THE PRESCENCE OF ------------- IN CHILDREN AND --------- INSUFFICIENCY IN ADULTS
MALABSORPTION PANCREATIC
CHOLESTEROL LEVELS ARE AFFECTED BY MANY FACTORS THAT CAN BE CATERGORIZED INTO --------,--------, AND -------- SOURCES
BIOLOGIC, CLINICAL ,AND SAMPLING
women generally have higher levels of --- cholesterol and lower levels of ----- cholesterol and ------------- than men due to higher estrogen levels
hdl total triglycerides
EPIDEMIOLOGIC STUDIES HAVE SHOWN THAT THE INCIDENCE OF HEART DISEASE IS SRTONGLY ASSOCIATED WITH ----- ----------- -------------
SERUM CHOLESTEROL CONCENTRATION
NORMALS FOR TRIGLYCERIDES
67-157 MG/DL
DISEASES ASSOCIATED WITH ABNORMAL LIPID CONCENTRATIONS ARE REFERRED TO AS ------------
DYSLIPIDEMIA
-------------------- IS THE LIPID ABNORMALITY MOST CLOSELY LINKED TO HEART DISEASE
HYPERCHOLESTERLEMIA
LIPID REFERENCE METHOD
ULTRACENTRIFUGATION
PRIMARY FORM OF LIPID STORAGE
TRIGLYCERIDES
HARDENING OF ARTERIES
ARTERIOSCLEROSIS
NEEDED FOR CELL PHYSIOLOGY AND MAKES HORMONES
CHOLESTEROL
LDL CALCULATIONS
total chol-(hdl chol.-plasma tg)
--------
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