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15 Cards in this Set
- Front
- Back
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What are the 4 transport forms of Lipids and where do they originate from?
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VLDL - Liver
Chylomicrons - Gut Epithelium LDL - Blood HDL - Liver |
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What do Chylomicrons provide in the sense of lipids in the body?
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They deliver lipoprotein breakdown particles into the liver, and supply with the dietary origin of cholesterol
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The liver makes 60% of cholesterol requirements. what is the regulating step of its production?
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HMG COA Reductase is the rate limiting enzyme in the production of Cholesterol.
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WHY does the liver need cholesterol?
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To produce VLDL and Bile Salts
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Why are VLDLs so amazing?
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They provide fatty acids to other parts of the body. Leaving behind LDL particles.
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What is an LDL Particle?
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carry alipoprotein B-100, mediate the uptake of LDL to cells
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Whats a HDL?
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They transfer cholesterol from the tissue to LDL = Cholesterol from tissues to liver
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What is Hyperliponatremia?
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Can be genetic (primary)
or you could be fat and unhealthy (secondary) LDL is NOT Good |
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Why does LDL suck so much?
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Elevated LDL means you are at increased risk of clogging your arteries (artheroschlerosis) esp when LDL kicks out HDL and the ratio is rubbish.
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How would you treat Primary Hyperliponatremias?
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Drugs!!!!!!
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How do you treat the fat lazy peeps? (Secondary Hypernatremia)
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Lose weight
Exercise
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How do Bile Acid Sequestrants work?
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Removes Bile acids in gut lumen
Dosage is high - not very compliant for clinical |
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What are statins?
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Inhibit HMG-COA Reductase
they look similar to the physiological enzyme substrate Liver has to compensate for the lack of blood circulating LDL and so it takes in any LDL, reducing the circulating LDL further. Most important Lipid Lowering Drug |
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What are Nictontic Acids?
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Activate endothelial lipoprotein Lipase = Lowering triglyceride levels
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What are Fibrates?
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Lower concentrations of LDL and VLDL. May cause damage to liver or skeletal muscle
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