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8 Cards in this Set
- Front
- Back
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Ilac gruplari |
Hmg-coa reductase=statins Resins Fibrates Ezetimibe Niacins |
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Hmg-coa reductase inhibitors STATINS P450 |
Atorvastatin-rosustatin Cholesterol sentezi inhibisyonu (Rate limitting stepte) Tg azaltir Ldl receptor/hdl artar Ck aminotransferase arttitr Teratogenic
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Resins COLESTIPOL |
Safraya ve steroidlere baglanir Reabsoprtion onler Ldl receptor arttirir pruritus azaltir Familial hiperglisemi hastalarinda kullanilmaz |
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EZETIMIBE |
Sterol transporter inhibitor (NPCIL1)=mediates kolestrol gis uptake Inhibit reabsorption in bile Phytosterolemiada kullanilir Hepatotoxic statinlerle kullanilirsa
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NIACIN |
Vldl sekresyonu azaltir Apoa1 catabolizmasini azaltir Fibrinojen⬇️plasminojen⬆️ Flushing hepatotoxic hiperurisemi khidrat tolerance |
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Fibrates FENOFIBRATE GEMFIBROZIL |
Adipose lipoprotein lipase⬆️ Fatty acid oxidation⬆️ Apo1-2⬆️ apoc2 vldl⬇️ Nausea skin rashes blood count⬇️ Anticoagulanlarla reaksiyon |
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Hmgcoa reductase-ezetimibe |
Hepatotoxic |
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Hmgcoa reductase-niacin |
Myopathy |
