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13 Cards in this Set
- Front
- Back
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What are statins?
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HMG CoA reductase inhibitors
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Which drug class is used for reducing LDL-C levels
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statins
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Which drug class would be used to increase HDL
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niacin
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Which drug class would be used to decrease triglycerides
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Fibric acid derivatives
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Which statins are most potent and preferred in homozygous LDL receptor deficiency
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Atorvastatin and Rosuvastatin
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Adverse reactions to statins
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elevated serum aminotransferase activity
muscle injury (myalgia due to decreased CoQ synthesis) |
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Examples of bile acid binding resins
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colestipol (Cholestid)
Cholestyramine (Questran, Locholest, Prevalite) Colesevelam (Welchol) |
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MOA for bile acid binding resins
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bind to bile acids in the intestinal lumen and prevent reabsorption-->increased liver bile acid excretion and larger need for liver cholesterol
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MOA of Ezetimibe
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blocks NPC1L1 which inhibits the absorption of cholesterol in enterocytes-->increased LDL receptor expression so less LDL in circulation
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Adverse effects of Niacin
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vasodilation
nausea and abdominal discomfort contraindicated in pt with peptic ulcer disease elevated aminotransferase levels hyperpigmentation (acanthosis nigricans) hyperuricemia macular edema |
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What are fibric acid derivatives
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Gemfibrozile (Lopid)
Fenofibrate (Tricor, Antara, Lofibra) |
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MOA of fibric acid derivatives
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upregulation of ApoA1, ApoA2, and LPL expression
down regulation of ApoCIII expression |
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How to decrease triglyceride levels
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Omega 3 fatty acids (in fish oil)
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