Lipid Lowering, Diurectics And Antihypertensives

Front 1

lovastatin
simvastatin

Back 1

Statins- hypolipadaemic inhibit HMG CoA reductase, rate limiting enzyme for cholesterol synthesis

Front 2

cholestyramine

Back 2

Anion exchange resin
Prevents reuptake of bile acids from HPV, need to resynth cholesterol, therefore increased uptake

Front 3

clofibrate

Back 3

Stimulates lipoprotein lipase
lowers VLDLs and LDLs therefore FAs

Front 4

cromakalim
(lemakalim)

Back 4

K+ channel opener, opens ATP sensitive K+ channels in vascular smooth muscle, hyperpolarises and relaxes

Front 5

minoxidil

Back 5

K+ channel opener, opens ATP sensitive K+ channels in vascular smooth muscle, hyperpolarises and relaxes
(also used as anti baldness drug)

Front 6

propranolol

Back 6

Beta blocker, antagonist of beta adrenergic channels, lowers CO and b.p. and increases NA in CNS. side effects - bronchoconstriction, insomnia, depression

Front 7

frusemide
(furosemide)

Back 7

Sulphonamide
Loop diuretic, inhibits NA2ClK pump in LoH.
Side effects - hypokalaemia, metabolic alkalosis, low uric acid excretion (gout)

Front 8

Spironolactone

Back 8

K+ sparing diurectic
Antagonist of aldosterone steroid binding site. Canrenone when metabolised.
Prevents expression of Na+ channels when aldosterone high.

Front 9

mannitol

Back 9

osmotic diuretic
filtered but not reabsorbed, increases urine volume without increasing GFR.
USES - lowering intracranial pressure in emergencies, diuretic when patient has low GFR

Front 10

xipamide

Back 10

Thiazide diurectic
inhibits Na/Cl transport by competing with Cl-.
side effects - hypokalaemia, low uric acid excretion, high Mg+ excretion