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10 Cards in this Set

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lovastatin
simvastatin
Statins- hypolipadaemic inhibit HMG CoA reductase, rate limiting enzyme for cholesterol synthesis
cholestyramine
Anion exchange resin
Prevents reuptake of bile acids from HPV, need to resynth cholesterol, therefore increased uptake
clofibrate
Stimulates lipoprotein lipase
lowers VLDLs and LDLs therefore FAs
cromakalim
(lemakalim)
K+ channel opener, opens ATP sensitive K+ channels in vascular smooth muscle, hyperpolarises and relaxes
minoxidil
K+ channel opener, opens ATP sensitive K+ channels in vascular smooth muscle, hyperpolarises and relaxes
(also used as anti baldness drug)
propranolol
Beta blocker, antagonist of beta adrenergic channels, lowers CO and b.p. and increases NA in CNS. side effects - bronchoconstriction, insomnia, depression
frusemide
(furosemide)
Sulphonamide
Loop diuretic, inhibits NA2ClK pump in LoH.
Side effects - hypokalaemia, metabolic alkalosis, low uric acid excretion (gout)
Spironolactone
K+ sparing diurectic
Antagonist of aldosterone steroid binding site. Canrenone when metabolised.
Prevents expression of Na+ channels when aldosterone high.
mannitol
osmotic diuretic
filtered but not reabsorbed, increases urine volume without increasing GFR.
USES - lowering intracranial pressure in emergencies, diuretic when patient has low GFR
xipamide
Thiazide diurectic
inhibits Na/Cl transport by competing with Cl-.
side effects - hypokalaemia, low uric acid excretion, high Mg+ excretion