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17 Cards in this Set
- Front
- Back
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Name the Bile Acid Sequestrants (BAS)
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Cholestyramine, Colestipol, Colesevelam
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Example of Selective cholesterol absorption inhibitor. How does it work?
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Ezetimibe, binds on the brush border of the intestinal epithelial cell preventing cholesterol absorption, no effect on vitamin absorption
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How does the Bile acid sequestrants work?
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They exchange chloride ion for negaively chaged bile acid causes an increase in the number of LDL receptors in the liver
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Side Effects of Bile Acid Sequestrants?
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Compensatory induction of HMGCoa reductase enhancing cholesterol biosyntehesis partially negating the LDL drop
B. Raises Triglycerides C. Bloating D. Might affect absorption of Fat Soluble vitamins and other drugs |
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What does Nicotinic Acid do in the body?
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Decreases VLDL production, raises HDL, and lowers LP(A)
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How does Nicotinic Acid do its function?
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Inhibits adipose breakdown of fat which is how liver makes VLDL.
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Side effects of Nicotinic Acid
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Effects:
A. Liver Transaminase activity B. Glucose levels C. Lipid Levels D. Uric Acid (gout) E. Increase flushing and Pruritis (Itch) |
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What is Niaspan
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Nicotinic acid derivative with less flushing reported
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Name examples of Fibric Acid Derivatives?
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Gemofibrozil and Fenofibrate (Newer)
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What does Gemfibrozil do in the body?
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Lowers Triglyceride and raises HDL, Lowers LDL slightly
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What are Gemfibrozil side effects?
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In hepatic and renal disease should be avoided
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when is fenofibrate used?
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Hypertriglyceridemia in patients with pancreatitis
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How do Statin's work?
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They block the HMG-Coa reducatse enzyme blocks its ability to produce cholesterol so upregulates LDL-R to take out cholesterol from body.
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Side Effects of Statins?
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Increase Transaminase activity (3x stop taking it), Myositis (muscle pain- elevated CPK activity)
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If primary problem is elevated LDL what do you use?
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Use Statins, if doesn't work use Niacin or Ezetemibe
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If primary problem is Low HDL?
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Start Fibrate, **Niacin, or statin
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What are the lipid-lowering agents?
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Statin, Fibrate, Niacin, Bile Acid Sequestrants, Inhibition of Cholesterol Absorption (Ezetimibe)
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