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14 Cards in this Set
- Front
- Back
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pharmacological treatment for lipid lowering
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bile acid sequestrants, HMG-CoA inhibitors, Fibrates, Niacin, HRT in women
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Name some bile acid sequestrants
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cholestyramine, colestipol, colesevelam
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Mechanism of action of bile acid sequestrants
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bind to bile acids, increase excretion
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Adverse effects of Bile Acid Sequestrants
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GI intolerance including constipation, nausea, GI irritation, fat soluble vitamin deficincies, ONLY AVAILABLE PO AND POWDER, SHOULD NOT BE ADMINISTERED WITH ANY OTHER MEDS
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HMG-CoA reductase inhibitors?
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statins, available PO only, administered HS because cholesterol things happen at night
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What do you use statins for?
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hyperlipidemia, slow progression of CAD and to prevent MI in patients at risk for MI
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Adverse effects of statins
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mild GI effects, headache, dissiness, blurred vision, elevated liver enzymes, rhabdomyolysis
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increased risk of rhabdomyolysis when taken with
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gemfibrozil
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Mechanism of action of fibrates
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decrease hepatic production of LDL and triglycerides (fenofibrate, gemfibrozil)
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adverse effects of fibrates
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GI effects
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mechanism of action of niacin
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increase rate of triglyceride removal from plasma, also reduces LDL and increases HDL
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adverse effects of niacin
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cutaneous flushing, nausea and abdominal pain
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mechanism of action of ezetimibe
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inhibits cholesterol absorption in s. intestine
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what do you use ezetimibe for
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monotherapy or with statins to reduce LDL
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