Lipid-Lowering Agents

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Lipid Lowering Agents

Drugs used to lower blood cholesterol and triglyceride.

Side effects: Interference with liver function, gastrointestinal alterations(steatorrhea,excess fat in feces), Flushing and pruritis(itching), constipation, gas, nausea, or heartburn

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Generic Name: Cholestyramine
Trade Name: Questran

Action: Act by binding bile acids. Cause more cholesterol to be converted to bile acids then removed through the gastrointestinal tract.

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Generic Name: Nicotinic acid
Trade Name: Niacin

Action: Nicotinic acid inhibits lipolysis of adipose tissue and secretion of lipoproteins by the liver thereby lowering levels of both LDL cholesterol and triglycerides.

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Uses: This medicine is a vitamin used to treat or prevent low levels of niacin.

Side effects: a temporary feeling of warmth or flushing of the skin, itching, headache, dizziness, nausea, bloating, gas, or heartburn.

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Generic Name: Gemfibrozil
Trade Name: Lopid

Actions: reduce the production and enhance the clearance of VLDL therapy decreasing triglycerides, increasing HDL and improving the HDL/total choles ratio

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Uses: a lipid-regulating agent used to lower cholesterol and triglyceride levels in blood.

Side effects: diarrhea, indigestion, or stomach pain

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Generic Name: Probucol
Trade Name: Lorelcol

Actions: Lowers total cholesterol including HDL.

Side effects: A poor drug for minimizing formation of atherosclerotic plaque.

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Generic Name: Lovastatin
Trade Name: Mevacor (lipitor)

Actions: Inhibits the key enzyme responsible for the synthesis of cholesterol.

Uses: Leading drug for treatment of high blood cholesterol/ taken Orally.

Side effects: constipation, may infrequently cause muscle damage, Contact your doctor if experience muscle pain/tenderness/weakness