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14 Cards in this Set
- Front
- Back
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Lipids |
Triglycerides Cholesterol FFA Phospholipids |
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Lipoproteins |
Lipid plus protein: chylomicrons, VLDL, LDL, HDL |
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Lipoprotein metabolism |
triglyceride enters bloodstream hydrolysis and reassembly chylomicron assembly liver lipid synthesis cholesterols ester synthesis HDLs help transport cholesterol from periph |
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Familial hyprcholesterolemia |
common Mendelian disorder receptor gene for LDL homozygotes, 5x elevation, AMI in 20s |
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Features of familial hypercholest... |
premature coronary athersclerosis xanthalasmas, skin, tendons diabetes mellitus or hypothyroidism |
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Lab tests and coronary artery disease |
LDL: increase for athersclerosis (200) HDL: protective (<40) Triglycerides: <150 normal |
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AMI |
history and physical is fundamental lab tests and EKG not definite atherosclerosis |
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Clinical presentation of AMI |
severe, substernal crushing chest pain no sign or symptoms ddx: AMI, pulmonary embolism, aortic dissection |
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Pathogensis of AMI |
sudden change in morphology of an atheromatous plaque (90%): intraplaque hemorrhaging, erosion, ulceration, rupture, fissuring platelet adhesion and aggregation |
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Myocardial response |
ischemia with loss of contractility damage after ~20 mins fatal arrhythmias release of intracellular macromolecules |
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EKG in AMI |
May be negative initially |
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WBC |
elevated after 12-24 hours due to dead tissue |
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RBC sedimentation rate |
rises soon after infarct remains elevates not specific |
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cardiac markers |
troponin and CK b-type naturetic peptide: increase with CHF, confirm CHF, overused |
