Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
components of chylomicrons
|
high: TGs
low: cholesterol and protein Apolipoproteins: B48, CII, E |
|
|
functions of chylomicrons
|
carry dietary TGs to peripheral tissues
carry dietary cholesterol to liver |
|
|
how VLDL is made
|
chylomicron + apoB-100
|
|
|
components of VLDL
|
moderate: TGs, cholesterol
low: proteins Apolipoproteins: B-100, CII, E |
|
|
components of LDL
|
low: TGs
moderate: protein high: cholesterol apolipoproteins: B-100 |
|
|
components of HDL
|
low: TG
moderate: cholesterol high: protein apolipoproteins: AI, CII, E |
|
|
VLDL function
|
take liver TGs to peripheral tissues
|
|
|
fate of VLDL
|
made by liver, converted to LDL by capillary lipoprotein lipase (remember the fibs inhibit lipoprotin lipase...telling a FIB will stop the LIe)
|
|
|
function of LDL
|
takes liver cholesterol to peripheral tissues
|
|
|
fate of LDL
|
made from VLDL, endocytosed by target cells with LDL receptors, degraded causing cholesterol release which stops further cholesterol uptake
|
|
|
function of HDL
|
activates LCAT to form cholesteryl esters, transfers apoCII and apoE to chylomicrons and VLDL
|
|
|
type I hyperlipoproteinemia (most common form)
|
no lipoprotein lipase = increased chylomicrons and TGs
|
|
|
type I hyperlipoproteinemia (less common form)
|
no CII = increased chylomicrons and TGs
|
|
|
type II hyperlipoproteinemia
|
no/defunct LDL receptor
IIa = increased LDL and cholesterol IIb = increased LDL, cholesterol and TGs Look for Achilles xanthomas |
|
|
type III hyperlipoproteinemia
|
no ApoE; "remnant disease"
increased cholesterol, TGs and IDL/chylomicron remnants |
|
|
type IV hyperlipoproteinemia
|
decreased catabolism/increased synthesis of VLDL
increased TGs (familial hypertrigylceridemia) Begins at puberty; acquired with ETOH-ism, diuretics, beta blockers, renal failure |
|
|
type V hyperlipoproteinemia
|
type I + type IV
|
