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8 Cards in this Set
- Front
- Back
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Linezolid mechanism
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Blocks formation of bacterial ribosomal initiation complex
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Linezolid resistance
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Mutations in 23S
Methylation of the 23S RNA via the cfr methyltransferase |
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Linezolid absorption
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100% oral bioavalability
THIS IS EXCEPTIONALLY HIGH. |
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Linezolid distribution
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Well distributed
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Linezolid metabolism
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Little metabolism
T1/2 = 5 hr. |
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Linezolid excretion
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80% renally
30% as unchanged drug |
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Linezolid adverse effects
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Headache
Hematologic toxicity: reduced platelet counts Serotonin toxicity: inhibition of MAO In long term use, peripheral or optic neuropathy |
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Linezolid clinical uses
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BAD INFECTIONS:
VR E. faecium MRSA VRSA |
