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8 Cards in this Set
- Front
- Back
True/False - Heparan sulfate and NO besides other actions also inhibit migration of smooth muscle cells into the intimal lyaer.
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True
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In a normal healthy artery, the endothelial surface serves 3 functions. Name them.
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1. non thrombogenic surface;
2. homeostatic vasodilation; 3. anti inflammatory |
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True/False - Injury to endothelial surface is often the result of non laminar flow around arterial branch points.
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True
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What are 3 negative consequences of modified (oxidized/glycated) LDL in the endothelium?
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1. mLDL is chemoattractant for monocytes; 2. increases endothelial expression of proinflammatory mediators; 3. mLDL absorbed by Macrophages does not feedback inhibit!
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What special compound is made excessively in the necrotic fibrous plaque core and what happens if rupture exposes this core?
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Tissue Factor a powerful coagulant is made in the core and if released is highly thrombogenic.
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True/False - Low tar and low nicotine cigarettes significantly decrease the occurrence of MI compared to regular cigarettes.
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False
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True/False - According to some studies, 3 years after cessation of smoking, the risk of CAD returns almost to normal.
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True
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Describe the reason for the increase in CAD with the onset of Menopause.
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Estrogen lowers LDL and lipA and raises HDL. As estrogen falls during menopause, women lose this protective effect.
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