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8 Cards in this Set

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True/False - Heparan sulfate and NO besides other actions also inhibit migration of smooth muscle cells into the intimal lyaer.
True
In a normal healthy artery, the endothelial surface serves 3 functions. Name them.
1. non thrombogenic surface;
2. homeostatic vasodilation;
3. anti inflammatory
True/False - Injury to endothelial surface is often the result of non laminar flow around arterial branch points.
True
What are 3 negative consequences of modified (oxidized/glycated) LDL in the endothelium?
1. mLDL is chemoattractant for monocytes; 2. increases endothelial expression of proinflammatory mediators; 3. mLDL absorbed by Macrophages does not feedback inhibit!
What special compound is made excessively in the necrotic fibrous plaque core and what happens if rupture exposes this core?
Tissue Factor a powerful coagulant is made in the core and if released is highly thrombogenic.
True/False - Low tar and low nicotine cigarettes significantly decrease the occurrence of MI compared to regular cigarettes.
False
True/False - According to some studies, 3 years after cessation of smoking, the risk of CAD returns almost to normal.
True
Describe the reason for the increase in CAD with the onset of Menopause.
Estrogen lowers LDL and lipA and raises HDL. As estrogen falls during menopause, women lose this protective effect.