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33 Cards in this Set
- Front
- Back
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2 "synthetic capability" liver tests |
albumin and pt INR |
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synthetic capability tests are a.. |
true measure of liver fxn |
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albumin tests good for.. |
measure of chronic liver fxn |
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hypoalbuminemia causes |
edema |
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hyperalbuminemia can result from |
severe dehydration |
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what does hepatic impairment do to INR |
increase INR |
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why does INR respond more quickly to hepatic insult than albumin |
bc clotting dacotrs have a shorter half-life than albumin |
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cholestatic disease's primary interference is |
synthesis or secretion oc bilirubin |
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define cholestasis |
failure of normal amounts of bile to reach the duodenum |
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cholestatic disease results in the.. |
accumulatino f substances normally secreted by the liver into the bile |
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what is the main issue w/ lab tests that monitor cholestatic disease |
can't distinguish where the obstruction has occurred (introa or extra hepatic) |
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2 lab tests to measure bile function |
ALP or GGT |
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6 drugs that may cause intrahepatic cholestasis |
amiodarone, erythromycin, estrogen, methyltestosterone, penicillamine, phenothiazine |
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what is elevates in pts that abuse alcohol or have alcoholic liver disease |
GGT |
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bilirubin is a product from ... metabolism |
hemoglobin |
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hallmark sign of hyperbilirubinemia |
jaundice |
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uncong. hyperbili due to (3) |
inc production, impaired uptake from the liver, impaired processing by liver |
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conjugated hyperbili caused by (2) |
decreased hepatocellular excretion or obstruction of biliary tract
and then “regurgitation” back into serum |
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what is used to assess hepatocellular inflammation and injury |
aminotransferases |
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name 2 aminotransferases |
Aspartate aminot. and Alanine Aminot |
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what kind of damage are they good markers of |
acute damage |
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which aminotransferase is more localized in the liver |
ALT |
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ammonia originates from.... due to... |
large intestine due to bacterial catabolism of protein |
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ammonia is taken up by the ... and then... and excreted by the... |
taken up by the liver and converted ito urea and excreted by the kidneys |
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2 causes of inc. serum ammonia |
hepatocellular disease or portal hypertension (avoid 1st pass effects) |
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accumulation of ammonia is associated w/ |
hepatic encephalopathy |
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what is the child pugh score |
severity index for cirrhosis |
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what 5 things is in the CP score |
bili, albumin, inr, encephalopathy, ascites |
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end stage liver disease 3 charactersitcs |
fibrosis, parenchymal archictecture is disrupted by interconnecting fibrous scars, parenchymal nodules created by regeneration of hepatocytes |
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what is thought to be the maker of collagen/fibrosis in ESLD |
activated stellate cells |
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activated stellate cells turn into.. |
fibroblasts |
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inc in fibrous tissue contributes to... |
resistance of portal blood flow = inc portal blood pressure |
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3 complications of portal HTN |
ascites, esophageal varcices, hepatic encephalopathy |
