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24 Cards in this Set
- Front
- Back
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State the possible genotypes for A1 phenotype
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A1/A1
A1/O A1/A2 |
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State the possible genotypes for A2 phenotyps
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A2/A2
A2/O |
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State the possible genotypes for A1/B phenotype
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A1/B
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State the possible genotypes for A2/B
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A2/B
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Naturally occuring cold antibody, IgM
Found in all group B and O persons 2-8% group A2 |
Anti-A1
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IgG found in high concentration in all group O individuals
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Anti-A, B
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Common cold agglutinin
Insignificant, but interferes with testing Ab frequency increases as antigen concentration decreases |
Anti-H
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Forward
Anti-A + Anti-B = Anti-A, B + Anti-A1 + Reverse A1 cells = B cells + O cells = |
A1
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Forward
Anti-A + Anti-B = Anti-A,B + Anti-A1 = Reverse A1 cells = B cells+ O cells = |
A2
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Forward
Anti-A + Anti-B = Anti-A,B + Anti-A1 = Reverse A1 cells + B cells + O cells = |
A2 (or A3) w/Anti-A1
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Forward
Anti-A + Anti-B + Anti-A,B + Anti-A1 + Reverse A1 cells = B cells = O cells = |
A1B
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Forward
Anti-A + Anti-B + Anti-A,B + Anti-A1 = Reverse A1 cells = B cells = O cells = |
A2B
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Forward
Anti-A + Anti-B + Anti-A,B + Anti-A1 = Reverse A1 cells + B cells = O cells = |
A2B (or A3B) w/Anti-A1
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Forward
Anti-A = Anti-B = Anti-A, B = Anti-A1 = Reverse A1 cells + B cells + O cells= |
O
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Forward
Anti-A = Anti-B = Anti-A,B = Anti-A1 = Reverse A1 cells + B cells + O cells + |
Bombay O
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Forward
Anti-A = Anti-B + Anti-A,B + Anti-A1 = Reverse A1 cells = B cells = O cells = |
B without Anti-A (low titer)
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Forward
Anti-A = Anti-B = Anti-A,B + Anti-A1 = Reverse A1 cells + B cells + O cells = |
Weak A subgroup w/anti-A1
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Forward
Anti-A = Anti-B + Anti-A,B + Anti-A1 = Reverse A1 cells + B cells = O Cells = |
B
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What is the linkage requirements for precursor substance in the formation of Lewis antigen
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Type 1 (beta1-3 linkage) carbon # 4 must be available for the Lewis gene to act upon
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A, B, and H genes code for these..
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Enzymes! (A-N-acetylgalactosaminyltransferase, H-L-fucosyltransferase, B-D-galactosyltransferase
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If the Le gene is inhereited but the individual is a non-secretor, what is the Lewis phenotype?
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Le(a+b=)
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Le/Le, Se/Se, H/h, O/O
-Ag on red cells? -In the saliva? -What is Lewis phenotype |
LeA, LeB, H
LeA, LeB, H Le(a=b+) |
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le/le, Se/se, H/H, B/O
-Ag on red cells? -In saliva? -What is the Lewis phenotype? |
B antigen
B and H Le(a=b=) |
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Le/le, se/se, H/h, B/B
-Ag on red cells? -In saliva? -What is the Lewis phenotype? |
LeA, H, B
LeA Le(a+b=) |
