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32 Cards in this Set
- Front
- Back
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translocation in CML
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t(9;22) bcr-abl hybrid
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translocation in Burkitt's lymphoma
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t(8;14) c-myc activation
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translocation in follicular lymphomas
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t(14;18) bcl-2 activation
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translocation in M3 type of AML
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t(15;17) responsive to all-trans retinoic acid
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translocation in Ewing's sarcoma
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t(11;22)
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translocation in mantle cell lymphoma
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t(11;14)
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Non-Hodgkins lymphoma associated with HTLV-1
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Adult T-cell lymphoma
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tumor marker PSA
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prostate-specific antigen; can also be elevated in BPH and prostatitis
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tumor marker prostatic acid phosphatase
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prostate carcinoma
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tumor marker CEA
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carcinoembryonic antigen= very nonspecific but produced by 70% of colorectal and pancreatic cancers; also gastric, breast, and thyroid medullary carcinoma
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a-fetoprotein
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normally made b fetus; hepatocellular carcinomas; nonseminomatous germ cell tumors of the testis
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B-hCG
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Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors
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CA-125
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ovarian, malignant epithelial tumors
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S-100
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melanoma, neural tumors, astrocytomas
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alkaline phosphatase
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metastases to bone, obstructive biliary disease, Paget's disease of bone
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Bombesin
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neuroblastoma, lung and gastric cancer
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TRAP
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Tartrate-resistant acid phosphatase; hairy cell leukemia- a B-cell neoplasm
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Ca-19-9
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Pancreatic adenocarcioma
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Calcitonin
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thyroid medullary carcinoma
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Assd. cancer HBV, HCV
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hepatocellular carcinoma
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Assd cancer- EBV
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Burkitt's lymphoma, nasopharyngeal carcinoma
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Assd cancer- HPV
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cervical carcinoma (16,18), penile/anal carcinoma
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Assd cancer- HHV-8 (kaposi's sarcoma-associated herpesvirus)
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Kaposi's sarcoma, body cavity fluid B-cell lymphoma
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Assd cancer- HIV
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primary CNS lymphoma
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Assd cancer- H.pylori
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gastric adenocarcinoma and lymphoma
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Assd cancer- Schistosoma
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Squamous cell carcinoma of transitional epithelial- bladder
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Paraneoplastic small cell lung carcinoma
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ACTH or ACTH-like peptide (Cushing's syndrome)
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Paraneoplastic- small cell lung carcinoma and intracranial neoplasms
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ADH- SIADH
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Paraneoplastic- squamous cell lung carcinoma, RCC, and breast carcinoma
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PTH-related peptide, TGF-B ,TNF, IL-1- hypercalcemia
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Paraneoplastic RCC, hemangioblastoma
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erythropoeitin- polycythemia
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Paraneoplastic- thymoma, small cell lung carcinoma
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Antibodies against presynaptic Ca2+ channels at neuromuscular junction- Lambert-Eaton syndrome (muscle weakness)
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Paraneoplastic- leukemias and lymphomas
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hyperuricemia due to excess nucleic acid turnover- gout, urate nephropathy
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