Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/55

Click to flip

55 Cards in this Set

  • Front
  • Back
Acute leukemia
rapid onset and rapidly progressive
over 50% blasts in bone marrow
numerous blast cells (> 20%)
pancytopenia
ALL
children, B cell types more common, bone pain is common, most have enzyme terminal deoxynucleotide transferase, good prognosis, PAS +
AML
Philadelphia chromo may be seen (poor prognosis), Auer rods, CD 13/33+, usually nonspecific esterase +, age 50, PAS -
M0
undifferentiated
M1
minimal difft, maturation
M2
with difft, maturation
M3
acute promyelocytic
M4
myelomonocyltic/myelomonoblastic
M5
pure monocytic/monoblastic
M6
erythroleukemia
M7
megakaryocytic
histiocytosis X
caused by langerhans cells from the monocyte lineage that infiltrate the lung
primarily affect young adults
worse with smoking
AML risk facotrs
radiation, benzene, alkylating agents, myeloproliferative disease, myelodisplatic syndrome, aplastic anemia, downs, fanconi, bloom
L1
small blasts
L2
large blasts with prominent nucleoli
L3
large blasts with cytoplasmic vaculoes
chronic leukemia
insidious onset and gradual progression
mature cells rather than blasts (<5% blasts)
can be either myeloid (CML) or lymphoid (CLL)
assoc with HSM, LAD
CLL
most common adult leukemia
adults over 50
95% have B cell markers, 10% progress to AML, smudge cells and AI hemolytic anemia
CML
may progress to AML (80%) or ALL (20%), adults 25-60, hyperplasia of all 3 cell lines but granulocyte precursors predominate
fatigue, ab pain, splenomeg, bleeding tendency
Philadelphia chromosome
t(9, 22)- CML
brc-abl
t (8, 14)
Burkitts
t(14, 18)
Follicular lymphoma
t(15, 17)
M3 AML
t(11, 22)
Ewings sarcoma
t(11, 14)
mantle cell lymphoma
ALL spread
CNS, testis
Hodkins
presence of Reed Sternberg cells (CD 30, CD15 pos, B cells); localized LN, painless LAD, assoc with EBV, bimodal distribution (young and old)
good prognosis in Hodgkins
increased lymphos
decreased RS
NHL
assoc with HIV, immunosuppression
multiple peripheral nodes, extranodal involement common
peak incidence 20-40
most common HL
nodular sclerosing: women, good prognosis, collagen binding lacunar cells
mixed cellularity HL
numerous RS cells
lymphocyte depleted
older males with disseminated disease
NHL most common in adults
follicular lymphoma (small cell cleaved)
bcl-2 involved in
apoptosis
NHL most common in children
lymphoblastic lymphoma; presents with ALL and mediastinal mass, very aggressive
Burkitt's lymphoma
most often in children; t(8,14) gene moves next to heavy chain Ig gene (14)
starry sky appearance; assoc with EBV
multiple myeloma
plasmacytoma; fried egg appearance (also seen with oligodendroglioma), produces large amount of IgG, IgA; destructive bone lesions and hypercalcemia, renal insufficiency, increased infections, anemia
Waldenstroms macroglobinemia
IgM spike
hyperviscosity symptoms, no bone lesions
associated with amyloid
tx: plasmapharesis
Reed Sternberg cells
distinctive tumor giant cell in HL; 2 halves as mirror images (binucleate) owl's eyes
most common leukemia in children
ALL
most common leukemia in adults
CLL
most common lymphoma
follicular
AML associatd with Downs
M7 AML
AML that are CD13 and 33 positive
M0-M6 AML
assoc with EBV
Burkitts and Hodgkins
Auer rods
M2 and M3 AML
long term celiac disease
intestinal T cell lymphoma
AML that is CD41 and CD 61 +
M7 AML
viscous blood, HA, plethora, splenomeg, low EPO
polycythemia vera
numerous basophils, splenomegaly, negative for leukocyte alk phos
CML
most common neonatal leukemia
M7 AML
associ wth Sjogren, Hashimotos thyroiditis and H pylori
marginal cell MALToma
acute leukemia positive for peroxidase
AML
solid sheets of lymphoblasts in marrow
ALL
PAS- acute leukemia
AML