Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
24 Cards in this Set
- Front
- Back
|
lymphoid neoplasms origin
|
B cells
|
|
|
most important symptom
|
increasing dyspnea on exertion
|
|
|
chest xray
|
large right sided superior mediastinal mass w/ mild tracheal deviation to the left
|
|
|
malignant cell in hodgkin's lymphoma
|
reed-sternberg (RS) cells
|
|
|
diagnosis
|
Hodgkin's lymphoma-presence of RS cells (Owls eyes on biopsy) make diagnosis pathognomonic
|
|
|
immunohistochemical stain
|
CD45- (only lymphoproliferative disoreder that's negative for CD45 expression)
|
|
|
diagnositc tests
|
CBC w/ differention, CMP, LDH, ESR
CT scan of chest, abdomen, pelvis PET-CT bone marrow biopsy cardiac echo pulmonary function tests |
|
|
associated factors of Hodgkin's
|
EBV infection
family history high standard of living immunosuppression young and old age seen in AIDS patients-prognosis better in young pts |
|
|
ann arbor staging
|
stages I-IV
|
|
|
one site/lymph node
|
stage 1
|
|
|
multiple sites on same side of diaphragm
|
stage II
|
|
|
sites on each side of diaphragm
|
stage III
|
|
|
multiple sites on each side of diaphragm or extranodal sites outside of lymphatics
|
stage IV
|
|
|
B symptoms
|
fever (>100.3)
night sweats-drenching wt loss (10% baseline wt in 6 months) |
|
|
case 1 diagnosis
|
Hodgkin's stage IIa (no B symptoms)
|
|
|
lymphoma classification
|
hodgkin's and non-hodgkin's
|
|
|
hodgkin's subgroups
|
nodular sclerosing
lymphocyte depleted lymphocyte predominant mixed cellularity |
|
|
non-hodgkin's subgroups
|
B cell and T cell
|
|
|
B cell lymphomas
|
aggressive-will kill w/out treatment
intermediate indolent-nonsymptomatic/not needed to treat for years |
|
|
T cell lymphomas
|
peripheral T cell
cutaneous T cell |
|
|
spread of hodgkin's lymphoma
|
relatively orderly fashion to cantiduous sites
|
|
|
mediastinal mass width >10 cm
ESR >50 (no B symptoms >3 lymph node regions involved B symptoms 1 extranodal site |
localized disease
|
|
|
albumin <4
Hgb <10.5 male age >45 stage IV WBC >15,000 lymphocyte<8% |
advanced disease
|
|
|
treatment options
|
radiation-early stages
chemotherapy w/ ABVD (adriamycin, bleomycin, venblastine, dactinomycin) for all stages |
