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29 Cards in this Set

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Age < 15 yo
ALL
May present with bone marrow involvement in childhood or mediastinal mass in adolescent males
ALL
Bone marrow replaced by tons of lymphoblasts
ALL
TdT+ (marker or pre-T and pre-B cells) and CALLA+
ALL
Most responsive to therapy
ALL
May spread to CNS and testes
ALL
t(12; 21) has the best prognosis
ALL
Age > 60 yo
SLL/CLL
Often asymptomatic; smudge cells present in peripheral blood smear
SLL/CLL
Warm antibody autoimmune hemolytic anemia
SLL/CLL
Many mature lymphocytes in peripheral smear
SLL/CLL
Mature B-cell rumor in the elderly
Hairy cell leukemia
Stains TRAP (tartrate-resistant acid phosphatase) positive
Hairy cell leukemia
Median age of onset is 60 yo
AML
Auer rods present
AML
Increased circulating myeloblasts on peripheral smear
AML
Responds to all-trans retinoic acid (vitamin A) inducing differentiation of myeloblasts
AML
DIC is a common presentation
AML
Anemia, thrombocytopenia, neutropenia
AML
Age 30-60 yo
CML
Philadelphia chromosome
CML
Myeloid stem cell proliferation
CML
Presents with increased neutrophils, metamyelocytes, and basophils
CML
Splenomegaly
CML
May accelerate and transform to AML or ALL ("blast crisis")
CML
Very low leukocyte alkaline phosphatase due to immature granulocytes (vs. leukemoid reaction - mature cells)
CML
Responds to imatinib, a small molecule inhibitor or the bcr-abl kinase
CML
Many mature granulocytes
CML
What is an Auer rod
Peroxidase-positive cytoplasmic inclusions in granulocytes and myeloblasts. Commonly seen in AML - M3. Treatment of AML - M3 can release Auer rods, leading to DIC.