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29 Cards in this Set
- Front
- Back
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Age < 15 yo
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ALL
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May present with bone marrow involvement in childhood or mediastinal mass in adolescent males
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ALL
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Bone marrow replaced by tons of lymphoblasts
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ALL
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TdT+ (marker or pre-T and pre-B cells) and CALLA+
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ALL
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Most responsive to therapy
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ALL
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May spread to CNS and testes
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ALL
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t(12; 21) has the best prognosis
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ALL
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Age > 60 yo
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SLL/CLL
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Often asymptomatic; smudge cells present in peripheral blood smear
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SLL/CLL
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Warm antibody autoimmune hemolytic anemia
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SLL/CLL
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Many mature lymphocytes in peripheral smear
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SLL/CLL
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Mature B-cell rumor in the elderly
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Hairy cell leukemia
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Stains TRAP (tartrate-resistant acid phosphatase) positive
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Hairy cell leukemia
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Median age of onset is 60 yo
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AML
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Auer rods present
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AML
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Increased circulating myeloblasts on peripheral smear
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AML
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Responds to all-trans retinoic acid (vitamin A) inducing differentiation of myeloblasts
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AML
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DIC is a common presentation
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AML
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Anemia, thrombocytopenia, neutropenia
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AML
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Age 30-60 yo
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CML
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Philadelphia chromosome
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CML
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Myeloid stem cell proliferation
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CML
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Presents with increased neutrophils, metamyelocytes, and basophils
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CML
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Splenomegaly
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CML
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May accelerate and transform to AML or ALL ("blast crisis")
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CML
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Very low leukocyte alkaline phosphatase due to immature granulocytes (vs. leukemoid reaction - mature cells)
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CML
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Responds to imatinib, a small molecule inhibitor or the bcr-abl kinase
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CML
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Many mature granulocytes
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CML
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What is an Auer rod
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Peroxidase-positive cytoplasmic inclusions in granulocytes and myeloblasts. Commonly seen in AML - M3. Treatment of AML - M3 can release Auer rods, leading to DIC.
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