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112 Cards in this Set

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Anminal bite
Unasyn
5 formulations of Erythromycin
1. Erythromycin base
2. Erythromycin estolate
3. Erythromycin ethyl succinate
4. Erythromycin lactobionate (IV formulation)
5. Erythromycin ethyl succinate + sulfisoxazole
4. Erthromycin lactobionate
Erythromycin base, generic?
(3A4 and 1A2 inhibitor)
1. Ery-tab
2. E-mycin
3. Eryc
Severe AE of Erythromycin estolate?
Hepatoxicity
Generic name of Erythromycin ethyl succinate?
E.E.S. or EryPed
What is Erythromycin lactobionate? one unusual reversibile AE?
1. IV Erythromycin
2. Hearing loss
what is the brand name of
(Erythromycin ethyl succinate + sulfisoxazole)?
Pediazole, age > 2 months
Kaletra
Lopinavir/retionavir
Minocycline
1. Generic name?
2. why does need to take it with fluids? (similar to Fosmax)
1. Minocin or Dynacin
2. To decrease esophageal irriation
1. Tri-PAK
2. Z-PAK
3. Zmax ( for acute sinuitis and community acquired pnumonia)
1. Tri-PAK (500 mg #3)
2. Z-PAK (250 mg #6)
3. Zmax (2 g a single dose suspension form)

--- of azithromycin
Azithromycin
Zithromax, Zmax
What does 2 g of Z-max is used for?
gonorrhea
(not well tolerated --> vomiting; does must be repeated if vomiting occurs within hour)
Avelox
Moxifloxacin
(400 mg, brand only)
(risk of QT interval prolongation)
What is transient toxicity from Minocyclin?
transient vestibular toxicity
4 Common consuling points for tetracyclines.
1.
2.
3.
4.
1. Aviod sunlight (photosensitivity)
2. 2 hours before/4 hours after anacids, or Ca supplement(milk)
3. Avoid children and pregnant women (due to teeth staining)
4. Take with plenty of water (not milk) to avoid esophageal irritation
Tigecycline
Tygacil (related to minocycline)
What is "Pediazole"?
EES (erythromycin ethyl succinate + sulfisoxazole
Isoniazid + Vit B6 ( 25 mg PO QD) --> ?
To reduce the risk of peripherial neuropathy
example of Class Ia ?-->
procainamide
example of Class Ib ? --> for ventricular arrthymia
Lidocaine (CNS side effects)
example of Class Ic ? --> cleaner drugs; avoid in CHF patients
propafenone (Rythmol)
example of class II -->
propanolol (not beta-1 selective)
examples of Class iV? -->
Calcium channel blockers (CCBs)
example of class III? -->
1) blocks K channeel
prolonged refractory period
adenosine
adenocard
acordarone; pacerone
amiodarone
disopyramide
Norpace
flecainide
Tambocor
Procanbid, pronestyl
Procainamide
Sotalol
betapace
Mexitil
mexiletine
Ibutilide
Corvert
felodipine
plendil
isradipine
DynaCir
nifedipine
Procardia
nisoldipine
sular
Calan. isoptin
verapamil
Hypothyrodism is low in T4 or T3?
T4
Amiodarone can cause hyper- or hypothyrodism?
Hypothyrodism
Frovatriptan
Frova (Triptans: 5HT1 receptor antagonists; longest t 1/2 ~26 hours
Licorice
postmenopausal vasomotor symptoms
Darvon ( C-IV)
Propoxyphene (65 mg Tab)
Darvon-N (C-IV)
Propoxyphene (100 mg Tab)
Darvocet
Propoxyphene + APAP
Darvocet N-50
Propoxyphene + APAP
(50/325)
Darvocet N-100
Propoxyphene + APAP
(100/650)
Darvocet A500
Propoxyphene + APAP
(100/500)
Olanzapine + fluoxetine
Symbyax for bipolar indication
Magmas = ?
suspension
w/o --> ?
water in oil
o/w --> ?
oil in water (oil is internal phase)
uroxatral®
Renal + Liver precautions
Affects QT interval
Alfuzosin
Cardura®
Doxazosin (BPH and HTN)
Minipress®
Prazosin
Flomax®
Tamsulosin
a. Least orthostatic hypotension
b. Most ejaculatory problems
c. Preferred for the patients with poorly controlled angina, heart problems
Hytrin®
Terazosin (BPH and HTN)
3 alpha1-blockers are related to 1st dose syncope?
1. Doxazosin
2. Prazosin
3. Terazosin
Symptoms of orthostatic hypotension are...
1. dizziness,
2. hypotension
3. Postural hypotension
4. Syncope
What are the 2 5-alpha reductase inhibiotrs?
1. Avodart
2. Proscar

MOA: reduced prostate size (only indicated for enlarged prostate > 40 gm)
Avodart
dutasteride
Proscar
Finasteride
What are the 5 alpha1-adrenergic antagonists?
1. Alfuzosin (Uroxatral)
2. Doxazosin (Cardura)
3. Prazosin (Minipress)
4. Tamsulosin (Flomax)
5. Terazosin (Hytrin)

MOA: relax smooth muscle, improve urine flow and symptoms of BPH
Name 3 rapid acting insulin are required Rx.
1. Novolog
2. Apidra
3. Humalog
Name 2 long-actinf insulin required Rx.
1. Levemir
2. Lantus
Which insulin canbe given SC/IM.IV?
Regular
Which insulin are cloudy.
1. Humulin N
2. Novolin N
3. Mixtures
Humalog, Novolog, Apidra are...
Rapid-acting insullins

Onset: 10-15 nibutes
What is Somogyi effect? Hyper- or hypo-glycemia?

1) S/Sx?
2) Tx?
Rebound hyperglycemia

1) Low BS @3:00 am, cortisol released --> hyperglycemia
2) Decreased PM NPH dose, or eat a small snack at HS
What is Dawn Phenomenon?

1) Tx?
A rise BS between 0400-0800 am.

1) Increased NPH insulin, or move NPH to HS
Red-book?
List prescription, OTC and herbal drug products in the US and the average wholesale price (AWP), direct price and federal upper limit prices
Orange book (Approved drug products with therapeutic equivalence evaluations
1) bio-equivalency of generic products and NDC number

2) Check drug availablity
which book?
"US and International approved names, chemical na,e, therapeutic use, dose..."
Martindale
Which book?

"Stability and compatibility"?
Handbook on Injectable drug "Trissel"
Which Book?

"Drugs in pregnancy and lactation"
Briggs
Which books for antmicrobial/antiviral?
"Mandell"
"Vonte" and "The Sanford Guide"
USP DI (drug information)
3 volume set.

1) Volume I
2) Volume II
3) Volume III
1) DI for health professional
2) Information for patient
3) Approved drug products and legal requirements (similar to orange book)
What is "ABC" book?
Approved Bioequivalency Codes (updated monthly)
What is chronic hypochlorhydria?
Long-term use PPI. Gastric bacteria overgrowth
Cimetidine + phenytoin -->DDI (?)
Increased [phenytoin] thru inhibition of phenytoin hepatic metabolism
Cimetidine + ketoconazole --> DDI (?)
Decreased [ketoconazole] due to increased gastric pH
Cimetidine + Tacrolimus --> DDI (?)
Increased [Tacrolimus]
What are the 2 drugs used to treat pain ass. with IBS?
1. Dicyclomine (Bentyl)

2. Hyoscyamine (Levsin)
What is Lubiprostone (Amitiza)?

USe: Idiopathic constipation in adult population

24 mcg capsule BID with food
Cl- channel activators; open Cl- channels on apical (luminal) surface of GI epithelium
Treatments for IBD.
1.
2.
3.
4.
1. Aminosalicylates (5-ASA)
2. Corticosteroids
3. Immunomodulators
4. Biological therapy
List 2 classes of meds are used to treat BPH.
1. alpha-1 adrenergic receptor antagoinsts

2. 5-alpha-reductase inhibitors
DHA (docosahexaenoic) and EPA (Eicosapentaenoic) are...
Omega-3 FA
Feverfew
Prevention and treatment of migraine
Licorice
Treatment of PUD
Drug recall classifications:
Cat I --> Cat III
from the most serious to least serious
FDA Limits

Antihistamine: no youner than ? y.o.
< 6yrs
FDA Limits

Inability to rinse Fluroide rine: no younger than ? y.o.
< 6 yrs
FDA Limits

Little need for the product: 1) Syrup of ipecac
2) sunscreen

no youner than ? y.o.
1. < 6 months

2. < 6 months
FDA Limits
Conditions refelcrs serious conditions:

1. KOH toothpaste

2. Hemorrhoidal tx

no youner than ? y.o.
< 12 years old
If pt is allergy to chrysanthemums, which OTC product pt should avoid.
RID (Piperonyl butoxide + pyrethrins)
Home UTI testing product is to detect ? ass. with G (-) bacteria.
Nitrites
What insulins are available OTC?
Humulin R
Humulin N
Humulin 70/30
Doses of actived charcoal.

1) < 1 yr
2) 1-12 y.o
3) >12 y.o
1) 20-25 grams
2) 25-50 grams
3) 25-100 grams
uric acid --> allantoin

by which enzyme?
uricase

(allantoin is more soluble than uric acid)
List drugs can increase uric acid levels.

1.
2.
3.
1. Thiazide (increased uric acid reabsorption)

2. low dose ASA (decreased uric acid claerance)

3. niacin, PZA, ethambutol, and cyclosporin
TXN for acute gouty attack.
1.
2.
3.
1. NSAIDs (DOC)
2. colchicine
3. corticosteroids
List 2 drugs lowering uric acid.
1. Probenecid (preferred younger patients)

2. Allopurinol (perferred if Urinary excretion of UA > 1000 mg/day)
Colchicine (starts within 12 hour gouty attack)

1) max PO dose? IV dose?
2) main AE
1) Max PO: 8 mg/day, IV: 4 mg/day

2) diarrhea

(av
Probenecid (Benemid)
INcreased uric acid excretion
risk of gouty flare

- not effective for Crcl<50
- keep alkaline urine or plenty of flid intake
Allopurinol (Zyloprim) not for acute gouty attack.

1) main AE
2) dose adjustment in transplant pt by? %
3) consul pts
DO not use durinf acut gouty attack
1. Rash
2. 70%
3. drink plenty points
Albuterol + Strattera --> DDI (?)
Increased heart rate
What is the
1. max dose of Strattera?
2. Initial dose for pediatrics?
1. 100 mg/day

2. 0.5 mg/kg QD, and then 1.2 mg/kg/day (in divided doses)
List 5 side effects of Strattera and stimulants?
1. Dry mouth
2. Insomia
3. Increased heart rate and BP
4. Upset stomach
5. wt loss
6. headache
List drugs aprroved for OCD in children.
1. ZOloft

2. Luvox
List 3 monitoring parameters for clozapine.
1. agranulocytopenia
2. seizure
3. cardiomyopathy
max dose:

1) IM Geodon
2) IM Zeprexa
1) IM Geodon 40 mg/24 hours

2) IM Zeprexa 30 mg/24 hrs
How often you give

1) Haldol Dec

2) Consta
1) Q month

2) Q 2 weeks
BBW for depakote.
1)
2)
3)
1. Hepatotoxicity
2. tetragenicity
3. pancreatitis