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12 Cards in this Set
- Front
- Back
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Legionella - Characteristics
Pleomorphic gram-_____ rod Legionaminic Acid Motility: Yes or no? spore forming: yes or no? biofilm producer? ____ Legionella genus - 56 species Legionella pneumophilia – 16 serogroups 3.5Mb Genome ~3000 genes |
Legionella - Characteristics
Pleomorphic gram-negative rod Legionaminic Acid Motile, non-spore forming biofilm producer Legionella genus - 56 species Legionella pneumophilia – 16 serogroups 3.5Mb Genome ~3000 genes |
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Legionalla lives in water. Vector is? Mode?
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Protozoa. Aersol droplets
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Legionella – Disease Presentation
Signs: Fever, myalgia, cough (maybe) Pneumonic vs. Pontiac form Pneumonic rapidly progressive Death is Coming (DIC) Pontiac - limiting 15% mortality rare outbreaks - 50% |
Legionella – Disease Presentation
Signs: Fever, myalgia, cough (maybe) Pneumonic vs. Pontiac form Pneumonic rapidly progressive Death is Coming (DIC) Pontiac - limiting 15% mortality rare outbreaks - 50% |
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Legionella - Epidemiology
No __________-__________ transmission Environmental factors 8k – 18k hospital admissions Total US cases likely higher Spring & Early Fall Attack rate 5% |
Legionella - Epidemiology
No human-human transmission Environmental factors 8k – 18k hospital admissions Total US cases likely higher Spring & Early Fall Attack rate 5% |
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Secretion type system used?
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IV.
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Legionella - Diagnostics
Confirmation tests? |
Urinary antigen assay and culture of respiratory secretions.
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Legionella – Treatment/Prevention
In-patient: Erythromycin 2-4g q24h IV (3-5 days) Rifampin 300mg BID PO (2-3 weeks) Out-patient Options: Levofloxacin Azithromycin Doxycycline No ________ exists. |
Legionella – Treatment/Prevention
In-patient: Erythromycin 2-4g q24h IV (3-5 days) Rifampin 300mg BID PO (2-3 weeks) Out-patient Options: Levofloxacin Azithromycin Doxycycline No human vaccine exists. |
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Mycoplasma - Characteristics
Pleomorphic bacteria. Lack ____ _____! ____ layer membrane Poor staining Smallest bacteria (<5% bacillus) Fried egg Genome: 800 Kbps! (~680 genes) 16S sequence indicates relatedness to G+ species 1/6 of E. coli genome |
Mycoplasma - Characteristics
Pleomorphic bacteria. Lack cell walls! Triple layer membrane Poor staining Smallest bacteria (<5% bacillus) Fried egg Genome: 800 Kbps! (~680 genes) 16S sequence indicates relatedness to G+ species 1/6 of E. coli genome |
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Mycoplasma – Disease Presentation
Fever, cough, headache and malaise ID50: <100 CFUs Mild pulmonary symptoms Extrapulomary disease syndromes Ears, throat (15%) Other sites (<2%) |
Mycoplasma – Disease Presentation
Fever, cough, headache and malaise ID50: <100 CFUs Mild pulmonary symptoms Extrapulomary disease syndromes Ears, throat (15%) Other sites (<2%) |
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Mycoplasma - Epidemiology
___% pneumonias in US _____ spread 2-3 week incubation Epidemics 4-6 years Attack rate 60% |
Mycoplasma - Epidemiology
10% pneumonias in US Droplet spread 2-3 week incubation Epidemics 4-6 years Attack rate 60% |
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Mycoplasma - Diagnosis
Stained ______ Serology Complement fixation Ig_ - which type? PCR |
Mycoplasma - Diagnosis
Stained sputum Serology Complement fixation IgM PCR |
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Mycoplasma – Treatment/Prevention
Azithromycin Levofloxacin Doxycycline No Human vaccine exists |
Mycoplasma – Treatment/Prevention
Azithromycin Levofloxacin Doxycycline No Human vaccine exists |
