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106 Cards in this Set

  • Front
  • Back
What is the age of the youngest adult according to medical legal issues in Texas?
18
What is the age of the oldest pediatric according to medical legal issues in Texas?
17
When concerns are of a medical physical nature such as those dealing with intubation, what is the age cut-off for pediatric?
?
What three drugs can be given intranasally?
Versed (midazolam) IN for Seizures only: 0.1 mg/kg to 0.3 mg/kg IN
Narcan (naloxone): 2.0 mg IN (I mg per nostril)
fentanyl: 1-2 mcg/kg repeated in 15 minutes / max dose 100 mcg.
What is the Metrocrest protocol for asystole?
CRITERIA:Pulseless/apneic
Asystole in two or more leads on ECG

TREATMENT: CABC's,CPR, O2, ECG, IV, Intubation

Consider treatable causes as soon as possible – The 6 H’s and 6 T’s

Epinephrine 1:10,000 1.0 mg IV, or 1:1,000 2.0 mg ET
Repeat every 3-5 minutes as 1.0 mg IV/2.0 mg ET

Atropine 1.0 mg IV/2.0 mg ET
Repeat every 3-5 minutes up to 3 mg

NG intubation (Full Paramedic only)

LIMITED PROTOCOL
Sodium bicarbonate 1 mEq/kg IV if metabolic acidosis likely

Consider Termination of Resuscitation (See Field Termination of Resuscitation protocol)

MEDICAL CONTROL

None
ET epinephrine, given in a 1:1,000 concentration, should be diluted with NS to a total volume of (blank to blank) cc prior to administration.
8 - 10 cc
Protocol for PEA
PULSELESS ELECTRICAL ACTIVITY

CRITERIA:
Pulseless/apneic
Any ECG rhythm other than V-fib, V-tach, or asystole

TREATMENT:
CABC's, CPr, O2, ECG

Intubate
IF indicated (Full Paramedic only): Surgical airway
IF DUE TO SURGICAL PROBLEM OR INJURY, TRANSPORT NOW
Consider treatable causes as soon as possible – The 6 H’s and 6 T’s
IF tension pneumothorax (Full Paramedic only):
Needle chest decompression

IV
Epinephrine 1:10,000 1.0 mg IV, or 1:1,000 2.0 mg ET
Repeat every 3-5 minutes as 1.0 mg IV/2.0 mg ET

IF bradycardic rhythm:
Atropine 1.0 mg IV/2.0 mg ET
Repeat every 3-5 minutes up to 3 mg total

TCP if bradycardia refractory to Atropine

NG intubation (Full Paramedic only)

LIMITED PROTOCOL

Sodium bicarbonate 1 mEq/kg IV if metabolic acidosis likely

MEDICAL CONTROL
None
What are the 6 H's and T's?
The 6 H’s: Causes
Hypovolemia

Hypoxia
Hydrogen Ion
Hypo-/Hyperelectrolytes
Hypo-/Hyperglycemia
Hypo-/Hyperthermia

The 6 T’s:
Tablets
Trauma
Tamponade
Tension Pneumothorax
Thrombosis
Thrombosis
Protocol for pulseless Vtach or VFib: What is the proper J. setting for the Philips Biphasic monitor?
150j first shock
150j second shock
150j third shock
In Pulseless VTach/Vfib, what medication do you push after IV is established and 1 mg Epinephrine has been administered?
IF IV access obtained:
Amiodarone 300 mg IV

Repeat Amiodarone 150 mg IV after 3 - 5 minutes
In Pulseless VTach/Ffib, what medication do you push if IV/IO is not established and 2 mg Epinephrine has been administered via ET tube?
IF no IV access obtained:
Lidocaine 3.0 mg/kg ET
What drug should you administer in pulseless VF refractory to IV Amiodarone (5 mins after second dose):
Lidocaine 1.5 mg/kg IV/3.0 mg ET Repeat in 5 min as 1.5 mg/kg IV/3.0 mg ET
In the "limited" protocol, what should be given for Torsades de Pointes or refractory Vfib?
2G IV Mag sulfate
In the "limited" protocol, what should be given for Vfib if metabolic acidosis is suspected?
1 mEq per/kg sodium bicarb
Ventilations during CPR should be delivered at a rate of (Blank) breaths/min without stopping compressions.
8 to 10 breaths/minute
Compressions during CPR should be hard and fast and allow complete recoil of the chest wall. The rate for compressions delivered should be (blank) per min.
100 per minute
ET epinephrine, given in a 1:1,000 concentration, should be diluted with (blank)....
NS to a total volume of 8 - 10 cc prior to administration.
ACLS guidelines list (blank 1) as the preferred antiarrhythmic for VF. If the patient remains in VF 3 - 5 minutes after the initial dose of (Blank 2), repeat a dose of (blank 3). Wait 5 minutes after the second dose of the drug to begin Lidocaine therapy.
Blank 1 amiodarone
Blank 2 300 mg
Blank 3 150 mg
ACLS guidelines list amiodarone as the preferred antiarrhythmic for VF. If the patient remains in VF 3 - 5 minutes after the initial dose of 300 mg of amiodarone, repeat a dose of 150 mg. Wait 5 minutes after the second dose of amiodarone to begin (blank).
Lidocaine therapy:

DOSAGE:
IV Push:
• PVC's or V-Tach with a pulse: 1.0 mg/kg initial dose
• Repeat every 5 min as 0.5 mg, up to 3 mg/kg
• V-Fib: 1.5 mg/kg initial dose
• Repeat once in 5 min as 1.5 mg/kg

Infusion:
• Adult: 2 to 4 mg/min of 4 mg/ml concentration
• Pediatric: 20 - 50 mcg/kg/min or 4 mg/ml concentration
Limit the number of antiarrhythmic medications to no more than (blank). Finish administration of the first antiarrhythmic before beginning the second antiarrhythmic.
two
Under "LIMITED PROTOCOL"
in the "POST RESUSCITATION MANAGEMENT" protocol, (Blank) should be given if the pt. is still hypotensive 5 min after conversion from any rhythm, EXCEPT a hemorrhagic PEA (which becomes perfusing after a fluid bolus).
Dopamine infusion 5-20 mcg/kg/min
By Metrocrest protocol, one of two drugs should be considered before cardioverting a conscious patient. Name the two drugs and their dose.
Lorazepam (Ativan) 2 - 4 mg IV is a benzodiazepine drug with short to medium duration of action. It has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant.[4] It is a powerful anxiolytic, and, since its introduction in 1977, lorazepam's principal use has been in treating the symptom of anxiety.

Midazolam 0.05 - 0.1 mg/kg IV (Versed) is an ultra short-acting benzodiazepine derivative. It has potent anxiolytic, amnestic, hypnotic, anticonvulsant, skeletal muscle relaxant, and sedative properties
By Metrocrest protocols; what is the sequence of joules to convert by?
Synchronized cardioversion at 100 J, 200 J, 300 J, 360 J monophasic, or at biphasic equivalent
What two drugs are given in the Metrocrest "Limited" protocol to convert Unstable VTach w/pulse if 100j, 200j, 300j, 360j, Syncronized Cardioversion doesn't convert the pt.?
Amiodarone 150 mg IV infused over 10 minutes

IF resolved by Amiodarone:
Start an amiodarone drip 1 mg/min

Lidocaine 1.0 mg/kg IV
IF resolved by lidocaine:
Start a lidocaine drip 2 - 4 mg/min
Below and after the Metrocrest "Limited" protocol, what drug might M.C. order for refractory VTach for alcoholics, malnutrition, anorexia, prolonged diarrhea, etc?
Magnesium Sulfate 2.0 G Slow IV push may be ordered by Metrocrest for refractory V-Fib and V-Tach due to magnesium deficiency (alcoholics, malnutrition, anorexia, prolonged diarrhea, etc).
Midazolam is given in 0.5 to 1.0 mg increments, at 1-2 min intervals until the desired response (i.e., adequate sedation) is achieved OR maximum dose is given. What is the maximum dose for Midazolam when used for sedation?
Sedation: 0.05 - 0.1 mg/kg IV, titrated to effect up to 10 mg
If the patient is converted from the tachycardia after cardioversion, but prior to antiarrhythmic administration, begin a(an) (blank).
Amiodarone infusion.
You've been called to a patient having seizures. When you get to the scene, you find a 47 y.o.m. in a run down apartment with empty vodka bottles scattered throughout. The patient is apparantly in the postictle state. After assessing CABC's, obtaining first set of V.S., administer O2, and check D-stick which reads 28 you prepare to give the patient 25 G of D-50. What drug must be given before you administer 25 G of D-50 to this patient?
100 mg Thiamine IV or IM.
What drug/dose is given with TCA overdose with significant CNS or cardiovascular symptoms?
Sodium bicarbonate 1.0 mEq/kg IV

Followed by: Sodium Bicarbonate IV infusion 0.05 mEq/ml titrated to systolic BP > 90 mm/hg
What is the max dose for Narcan (naloxone)?
8 mg
What is the first dose of narcan given to a suspected OD of an opiate?
0.5 mg to 2mg up to 8 mg max
What is the method for administering O2 to suspected CO poinsoning victim?
IF suspected CO poisoning:
CPAP at 5 cm H2O
Your patient presents with the following symptoms:
Fever
Recent UTI symptoms
Urinary catheter
Rash
What do you suspect and what is your treatment?
Field Diagnosis: SEPSIS
TREATMENT:
CABC's

O2

V/S

ECG

IV: Fluid challenge 250 - 500 ml
• May repeat every 5 minutes if still symptomatic

Blood Glucose Determination: IF below 80 mg/dl, treat per hypoglycemia protocol

LIMITED PROTOCOL
IF hypotension refractory to 500 – 1000 ml IV fluid or continued fluid contraindicated:
Administer Dopamine infusion 5 - 20 mcg/kg/min
What facilities in the Dallas area have capibility of offering emergency hyperbaric facilities?
Hyperbaric Medicine:
Presbyterian – Dallas Methodist Medical Center
What is PAT?
paroxysmal atrial tachycardia
How do you treat PAT?
vagel maneuvers and possibly diltiazam if the PAT is symptomatic.

DOSAGE:
0.25 mg/kg administered over 2 minutes, up to maximum dose of 20 mg
Repeat once in 15 minutes if no conversion:
• 0.35 mg/kg administered over 2 minutes, up to maximum dose of 25 mg
What is Diltiazem administered for and what is the dosage?
Treated for narrow complex tachycardias such as SVT, PAT, PSVT, AFib and A Flutter with RVR.

First dose is 0.25 mg/kg
Second dose is 0.35 mg/kg
In the unconscious anaphylactic patient in whom IV access cannot be rapidly established, 1:1,000 epinephrine 0.5 mg may be injected directly into the (Blank).
sublingual tissue
What does "PRN" mean?
As needed
An anaphylactic patient who is unconscious should first receive what drug and dosage?
0.5 mg Epinephrine 1:10,000 IV
Or
0.5 mg Epi 1:1,000 SL
What is the dosage and medications for unconscious anaphylactic patient w/ IV access established?
0.5 mg Epinephrine 1:10,000 IV over 5 minutes.
50 mg. Diphenhydramine
125 - 250 mg Methylprednisolone (solumedrol)
What is the dosage and medication for unconscious anaphylactic patient with no IV access established?
Anaphylaxis
IF patient is unconscious:
Epinephrine 1:10,000 0.5 mg IV over 5 mins, or 1:1,000 0.5 mg SL injection
IF patient is conscious:
• Epinephrine 1:1,000 0.5 mg SQ

• Diphenhydramine
50 mg IV
• Methylprednisolone
125-250 mg IV
• Repeat previous dose of Epinephrine if
anaphylaxis not resolved
At what weight is the "cut off" for the administration of Terbutaline?
Terbutaline is contraindicated in patients < 35 kg
What does URI stand for?
Upper Respiratory Infection
A stable pt. presenting with PSVT receives (blank) for the first dose and it may be followed up with a second and third dose of (blank) may be given in two minutes if the first dose doesn't work.
6 mg Adenosine
12 mg adenosine
The primary indication for NG intubation is ......
for the decompression of the stomach for pts receiving positive pressure ventilation.
What is the dose for Methylprednisolone?
125 to 250 mg. IV or IM
What is the dose for Terbutaline?
.25 mg SQ or nebulized inhalation - may be repeated once in 15 minutes.

.25 mg. repeat PRN for premature labor contractions.
Dose and route for Thiamine is (blank).
100 mg IV or IM
What is the dose for Solumedrol?
125 - 250 mg.
What is the dose and route for Versed (medozolam)?
Sedation: 0.05 to 0.1 mg/kg up to 10 mg
Intubation: 0.1 to 0.3 mg/kg up to 20 mg
Seizure: 0.1 mg/kg IV and 0.3 mg/kg IN up to 5 mg.
Chemical Restraint: 0.1 mg up to 5 mg IV or up to 10 mg IM
Dose and route of Lorazepam:
Seizure: 2 to 4 mg IV or Bucal Mucosa if IV unobtainable.

Sedation: 2mg IV may be repeated once in 10 minutes.
What is a contraindication for Dopamine?
Hypovolemia
A patient with new onset CHF precents with pulmonary edema. What is the correct dosage of Furosemide?
0.5 mg/kg
If the pt was already taking furosemide, the dosage would be 1.0 mg/kg
IF still hypotensive 5 min after conversion from any rhythm, EXCEPT a hemorrhagic PEA (which becomes perfusing after a fluid bolus) give ......
Dopamine infusion 5-20 mcg/kg/min
Never give (blank) to a hypovolemic patient.
Dopamine
Nitroglycerin is contraindicated to pts with....
Hypotension
Hypovolemia
Increased ICP
Patient’s use of medication for erectile dysfunction within the past 48 hours
what is the correct dosage for acetaminophen?
15 mg/kg
Albuterol may be given to help releive pneumonia? (true or false)
False
What is the drug and dosage for bradycardia?
Atropine
0.5 mg every 5 minutes up to 3 mg
What two drugs, and their dosage are administered for PEA and Asystole?
1 mg Epinephrine 1:10,000
1 mg Atropine
What is the drug and dosage for organophosphate poisoning?
2 mg atropine q 5 minutes until symptoms resolve.
Dopamine may be used to improve BP on a pt. with suspected internal bleeding? (true or false)
False: Dopamine is contraindicated for hypovolemia.
Terbutaline is not used in patients less than (Blank)?
35 kg
The treatment for a COPD pt who has inadequate tidal volume for inhalation therapy should be treated as follows:
CPAP at 5 cmH2O with Albuterol 2.5 mg nebulized
inline Terbutaline 0.25 mg SQ
Repeat once in 10 min if dyspnea not relieved
PL: Name 1 antipyretic we carry that would assist a pediatric patient with febrile seizures along with the amount you would give for a 22 Lb patient.
Acetamenophen (15 mg/kg)
22Lbs = approx. 10kg.
150 mg
What is the dosage of acetamenophen?
15 mg/kg
Name three signs that distenguish a patient between stable and unstable tachycardia.
Altered LOC
Pulmonary edema
hypotension
Name three drugs and their dosage that we give IN.
Versed (medazolam)
Fentanyl 1-2 mcg/kg up to 100mcg
Naloxone (narcan) 2 mg/IN
What is the drug and dose for seizure if IV is established?
2-4 mg lorazopam (ativan)
What is the drug and dose for seizure if IV is NOT established?
Midazolam (versed) 0.3 mg/kg IN (up to 5mg)

Lorazepam (ativan) 0.4 mg/kg buccal mucosa
ACETAMINOPHEN (TYLENOL) SUSPENSION
Dosage:
ACETAMINOPHEN (TYLENOL) SUSPENSION

PHYSIOLOGICAL ACTIONS:
Reduces fever (antipyretic) by acting directly on the heat regulating center of the hypothalamus

THERAPEUTIC EFFECTS:
Reduces fever

INDICATIONS:
Fever of any etiology in pediatric patients

CONTRAINDICATIONS:
None

DOSAGE:
15 mg/kg, maximum dose 1 Gm

ROUTE:
PO
PR

SPECIAL NOTES:
Doses may be repeated every 4 hours as needed, not to exceed 75 mg/kg total in a 24 hour period.
Hepatic damage begins at overdoses of about 150 mg/kg

SIDE EFFECTS:
Rarely, gastric irritation
ADENOSINE (ADENOCARD)
ADENOSINE (ADENOCARD)

PHYSIOLOGICAL ACTIONS:
Directly blocks re-entrant mechanism in the atria and AV node
Decreases AV conduction

THERAPEUTIC EFFECTS:
Converts SVT.

INDICATIONS:
SVT, including Wolf-Parkinson-White syndrome

CONTRAINDICATIONS:
Sick-sinus syndrome (unless ventricular pacemaker is in place and functioning)
Second or third degree heart block
Ventricular tachycardia

DOSAGE:
Adult: 6 mg
• Repeat TWICE every 2 minutes as 12 mg if no conversion

Pediatric: 0.1 mg/kg up to 6 mg
• Repeat TWICE every 2 minutes as 0.2 mg/kg (max. of 12 mg) if no conversion

ROUTE:
RAPID IVP
See Adenosine Administration procedure

SPECIAL NOTES:
MUST be given very rapidly and as directly into the vein as possible
Repeat doses must be given in exactly two minutes
Will not convert A-fib or A-flutter


SIDE EFFECTS:
Brief dyspnea
Chest pressure
N/V
Hypotension
Significant cardiac pauses
Albuterol
ALBUTEROL (PROVENTIL, VENTOLIN)

PHYSIOLOGICAL ACTIONS:
Beta 2 agonist
Smooth muscle relaxant

THERAPEUTIC EFFECTS:
Bronchodilation

INDICATIONS:
Asthma
Exacerbation of COPD

CONTRAINDICATIONS:
Poor respiratory tidal volume
Tachydysrhythmias
Ventricular ectopy

DOSAGE:
2.5 mg in 2.5 (or 3) ml of NS

ROUTE:
Nebulized inhalation

SPECIAL NOTES:
See Nebulized Bronchodilation procedure
Therapeutic effects may last 2-3 hours

SIDE EFFECTS:
Tachydysrhythmias
Ventricular ectopy
N/V
Anxiety
Palpitations
Amiodarone
AMIODARONE (CORDARONE)

PHYSIOLOGICAL ACTIONS:
Prolongs intranodal conduction and AV node refractory period
Blocks beta receptors, sodium and potassium channels

THERAPEUTIC EFFECTS:
Antiarrhythmic

INDICATIONS:
Ventricular Fibrillation/Pulseless Ventricular Tachycardia
Stable Ventricular Tachycardia
Junctional Tachycardia, SVT, Atrial Flutter

CONTRAINDICATIONS:
Cardiogenic Shock
Symptomatic Bradycardia
Second or Third Degree AV Block

DOSAGE:
Pulseless Patient:
• 300 mg IVP
• Repeat dose of 150 mg after 3 - 5 minutes

Post-resuscitation Infusion:
• 1.0 mg/min
• Mix 100 mg in 100 ml, infuse at 60 gtt/min (minidrip)

Perfusing Patient:
• Mix 150 mg in 100 ml, infuse over 10 minutes

ROUTE:
IV/IO

SPECIAL NOTES:
Do not agitate or foaming may occur

SIDE EFFECTS:
Hypotension
Bradycardia
Aspirin
ASPIRIN (ASA)


PHYSIOLOGICAL ACTIONS:
Inhibits platelet aggregation
Diminished peripheral activity of prostaglandins

THERAPEUTIC EFFECTS:
Anticoagulant
Antipyretic
Analgesic

INDICATIONS:
Suspected AMI

CONTRAINDICATIONS:
Bleeding disorders
Active gastric/peptic ulcer
Hypersensitivity

DOSAGE:
160 - 162 mg

ROUTE:
PO

SPECIAL NOTES:
Instruct patient to chew pills and provide a small quantity of water if requested. This will increase absorption of the ASA and reduce its effects on the gastric mucosa.

SIDE EFFECTS:
Gastric irritation
Exacerbation of gastric ulcers
Atropine
ATROPINE

PHYSIOLOGICAL ACTIONS:
Vagolytic

THERAPEUTIC EFFECTS:
Increases heart rate
Increases AV conduction
Reverses organophosphate intoxication

INDICATIONS:
Asystole
PEA
Bradycardias
Organophosphate poisoning

CONTRAINDICATIONS:
2 Type II-Fixed AV Block
Complete (3o) AV Block

DOSAGE:
Adult:
• Asystole / PEA: 1.0 mg repeat every 3-5 minutes up to 3 mg
• Bradycardia: 0.5 mg every 5 minutes up to 3 mg
• Organophosphate poisoning: 2 mg every 5 minutes until symptoms resolve

Pediatric:
• 0.02 mg/kg; min dose 0.1 mg, max single dose 0.5 mg
• Repeat every 3-5 minutes until max dose of 2 mg (1 mg for infants) is reached

ROUTE:
IV/IO push
May be ordered IM as well in organophosphate poisoning
ET

SPECIAL NOTES:
Must be given rapidly
Inadequate or slowly administered doses may result in a reflex bradycardia


SIDE EFFECTS:
Tachydysrhythmias
Ventricular ectopy
Dry mouth
Dilated pupils
Dextrose 50
DEXTROSE 50%

PHYSIOLOGICAL ACTIONS:
Carbohydrate glucose source

THERAPEUTIC EFFECTS:
Raises blood glucose level

INDICATIONS:
Hypoglycemia, established or suspected
Altered mentation of unknown cause

CONTRAINDICATIONS:
Intracranial hemorrhage
Cerebral edema
Increased ICP

DOSAGE:
Adult:
• 25 - 50 G of 50% solution

Pediatric:
• 0.5 G/kg
o > 10 kg: 1 cc/kg of D50% solution
o < 10 kg: 2 cc/kg of D25% solution
 D25% is prepared by diluting equal parts D50% and NS

ROUTE:
IV/IO push
PO

SPECIAL NOTES:
Will cause severe tissue damage if extravasation occurs
MUST be preceded by thiamine in known or suspected alcoholics
Dextrose 25% can be made by diluting equal parts of NS and D50%, yielding 0.25 Gm/ml

SIDE EFFECTS:
Neurological symptoms in unprotected alcoholic patients if not preceded by thiamine
Diltiazem
DILTIAZEM (CARDIZEM)

PHYSIOLOGICAL ACTIONS:
Calcium channel blocker

THERAPEUTIC EFFECTS:
Slows AV node conduction
Prolongs AV node refractory period

INDICATIONS:
Atrial Fibrillation or Atrial Flutter with rapid ventricular response

CONTRAINDICATIONS:
Sick-sinus syndrome, unless ventricular pacemaker is in place and functioning
Second or third degree heart block
Ventricular tachycardia
Wolff-Parkinson-White syndrome (accessory bypass tracts)

DOSAGE:
0.25 mg/kg administered over 2 minutes, up to maximum dose of 20 mg
Repeat once in 15 minutes if no conversion:
• 0.35 mg/kg administered over 2 minutes, up to maximum dose of 25 mg

ROUTE:
IV

SPECIAL NOTES:
Use with caution in patients with severe CHF, acute MI, or cardiomyopathy
Observe for bradycardias in patients taking other medications which affect AV conduction (i.e. digitalis, beta-blockers).

SIDE EFFECTS:
Hypotension
PVC’s
DIPHENHYDRAMINE (BENADRYL)
DIPHENHYDRAMINE (BENADRYL)

PHYSIOLOGICAL ACTIONS:
Blocks histamine activity

THERAPEUTIC ACTIONS:
Reduces urticaria/itching and edema
Reverses extra-pyramidal symptoms

INDICATIONS:
Allergic reaction
Dystonic reactions

CONTRAINDICATIONS:
Asthma
Pregnancy
Intoxication from alcohol or depressants

DOSAGE:
Adult:
• 25 - 50 mg

Pediatric:
• 1 - 2 mg/kg, up to 25 mg

ROUTE:
IV
Deep IM

SPECIAL NOTES:
None

SIDE EFFECTS:
Sedation or drowsiness
Anti-cholinergic effects including wheezing
Blurred vision
DOPAMINE (INTROPIN)
DOPAMINE (INTROPIN)

PHYSIOLOGICAL ACTIONS:
Sympathomimetic; stimulates both Alpha and Beta receptors

THERAPEUTIC EFFECTS:
Increases heart rate
Increases blood pressure
Improves AV conduction

INDICATIONS:
Cardiogenic shock
Sepsis if hypotension refractory to IV fluid administration

CONTRAINDICATIONS:
Hypovolemia

DOSAGE:
5 - 20 mcg/kg/min, titrated to BP of 100 mmHg
 Shortcut for starting dopamine infusion drip rate:
o Patient’s weight in lbs/10, subtract 2 = starting gtt/min (minidrip set)
o i.e. Patient weighs 180 lbs, divide by 10 = 18, subtract 2 = 16 gtt/min

ROUTE:
IV infusion

SPECIAL NOTES:
Causes increased myocardial oxygen demand
Pre-mix solution is 800 mg in 500 ml (1600 mcg/ml)
Administer by starting drip using the formula above, using a minidrip set. Ensure the tubing is primed with dopamine as very small volumes are being administered. If no effect is seen after 5 minutes, increase the dose by doubling the drip rate every 5 minutes until systolic BP is 100 mm Hg or higher

SIDE EFFECTS:
Tachydysrhythmias
Ventricular dysrhythmias
Myocardial ischemia
EPINEPHRINE (ADRENALIN) 1:1,000
EPINEPHRINE (ADRENALIN) 1:1,000

PHYSIOLOGICAL ACTIONS:
Sympathomimetic; stimulates both Alpha and Beta receptors

THERAPEUTIC EFFECTS:
Bronchodilation
Increased systemic vascular resistance
Dilation of coronary arteries
Increased automaticity of myocardium

INDICATIONS:
Allergic reaction
Pediatric asthma
Adult asthma and COPD refractory to other interventions
Pediatric CPR, bradycardia, and refractory hypotension

CONTRAINDICATIONS:
Myocardial ischemia
Hypertension
Tachydysrhythmias
Pulmonary edema

DOSAGE:
Adult: 0.3 - 0.5 mg injection

Pediatric:
• Asthma / Allergic Reaction: 0.01 cc/kg
• CPR refractory to other efforts: 0.1 cc/kg
• Neonate: Use Epinephrine 1:10,000.
• Infusion: 0.1 - 1.0 mcg/kg/min.

ROUTE:
SQ
IV/IO, IV infusion
ET
SL (anaphylaxis)

SPECIAL NOTES:
Causes increased myocardial oxygen demand and increased heart rate
Infusion prepared by adding 1 mg of 1:1,000 to 100 ml NS (1 mcg/ml)


SIDE EFFECTS:
Ventricular ectopy
Tachydysrhythmias
Angina
Hypertension
Palpitations
EPINEPHRINE (ADRENALIN) 1:10,000
EPINEPHRINE (ADRENALIN) 1:10,000

PHYSIOLOGICAL ACTIONS:
Sympathomimetic; stimulates both Alpha and Beta receptors

THERAPEUTIC EFFECTS:
Increased systemic vascular resistance
Dilation of coronary arteries
Bronchodilation
Increased automaticity of myocardium

INDICATIONS:
Cardiac Arrest
Anaphylaxis

CONTRAINDICATIONS:
None in these settings

DOSAGE:
Adult:
• Anaphylaxis: 0.5 mg, repeat every 5 minutes as needed
• CPR: 1.0 mg, repeat every 5 minutes as 2.0 mg as needed

Pediatric:
• Anaphylaxis: 0.01 cc/kg repeat every 5 minutes as needed
• Neonate CPR: 0.1 cc/kg repeat every 5 min as needed
• CPR / Bradycardia: 0.1 cc/kg repeat every 5 minutes as needed

ROUTE:
IV/IO push
ET

SPECIAL NOTES:
None

SIDE EFFECTS:
Ventricular ectopy
Tachydysrhythmias
Angina
Hypertension
Palpitations
FENTANYL (SUBLIMAZE)
FENTANYL (SUBLIMAZE)

PHYSIOLOGICAL ACTIONS:
Analgesia
CNS Depression

THERAPEUTIC EFFECTS:
Analgesia

INDICATIONS:
Relief of severe pain related to trauma without hypotension

CONTRAINDICATIONS:
Head injury
Bradycardia
Hypotension
Respiratory depression/failure

DOSAGE:
Adult: 1-2 mcg/kg
• Max dose 100 mcg
• May repeat dose in 15 minutes – 300 mcg maximum per patient

Pediatric: 1-2 mcg/kg
• Max dose 50 mcg
• May repeat dose in 15 minutes – 150 mcg maximum per patient

ROUTE:
IV
IN
IM

SPECIAL NOTES:
Approximately 80 times more potent than Morphine
Respiratory depression secondary to Fentanyl can be reversed with naloxone
Cardiac chest pain and analgesia for burns should be treated with Morphine

SIDE EFFECTS:
CNS/respiratory depression
Hypotension
N/V
Bradycardia
Diaphoresis
FUROSEMIDE (LASIX)
FUROSEMIDE (LASIX)

PHYSIOLOGICAL ACTIONS:
Vasodilation
Diuresis

THERAPEUTIC EFFECTS:
Reduce blood pressure
Reduce pulmonary and peripheral edema

INDICATIONS:
CHF with pulmonary edema

CONTRAINDICATIONS:
Dehydration
Hypotension

DOSAGE:
0.5 - 1.0 mg/kg

ROUTE:
Slow IV push
IM

SPECIAL NOTES:
Immediate effects occur through vasodilation
Diuresis occurs about 15-20 minutes after administration
Administer 0.5 mg/kg if patient is not currently taking furosemide, and 1.0 mg/kg if patient is on furosemide

SIDE EFFECTS:
Hypotension
N/V
Hypokalemia
GLUCAGON
GLUCAGON

PHYSIOLOGICAL ACTIONS:
Causes release of liver glycogen which can convert to glucose
Positive inotropic agent through non- and non- receptors

THERAPEUTIC EFFECTS:
Raises blood glucose level.

INDICATIONS:
Hypoglycemia, established or suspected
Unable to obtain IV access for dextrose administration
-blocker overdose

CONTRAINDICATIONS:
Pheochromocytoma (adrenal gland tumor resulting in high levels of circulating epinephrine and norepinephrine)

DOSAGE:
Adult:
• 1 unit (1 mg)

Pediatric:
• 0.5 unit (0.5 mg).

ROUTE:
IM
IV for calcium channel blocker or -blocker overdose

SPECIAL NOTES:
Must be reconstituted prior to administration
May take up to 15 minutes for patient to respond
Glucagon is an inotropic agent that increases force of myocardial contraction through non-, non- receptors. It can be useful in mild to moderate shock induced by -blocker overdose. Glucagon should be administered with MC’s approval at 1-2 mg IV push. Vasopressors such as dopamine may also be required.

SIDE EFFECTS:
Occasional nausea/vomiting
LIDOCAINE (XYLOCAINE)
LIDOCAINE (XYLOCAINE)

PHYSIOLOGICAL ACTIONS:
Slows AV and intra-ventricular conduction
Increases VF threshold

THERAPEUTIC EFFECTS:
Inhibits refractory or recurrent V-Tach and VF
Suppresses PVC's

INDICATIONS:
PVC's (WITH CAUTION)
V-Tach
V-Fib
Prior to oral intubation of CVA or Head Injury patients

CONTRAINDICATIONS:
Bradycardia
Any heart block

DOSAGE:
IV Push:
• PVC's or V-Tach with a pulse: 1.0 mg/kg initial dose
• Repeat every 5 min as 0.5 mg, up to 3 mg/kg
• V-Fib: 1.5 mg/kg initial dose
• Repeat once in 5 min as 1.5 mg/kg

Infusion:
• Adult: 2 to 4 mg/min of 4 mg/ml concentration
• Pediatric: 20 - 50 mcg/kg/min or 4 mg/ml concentration

ROUTE:
IV/IO push
IV/IO infusion
ET

SPECIAL NOTES:
Use ½ dose in patients older than 70 years
A DRIP USUALLY (but not always) FOLLOWS PUSH ADMINISTRATION
Use the infusion to maintain serum levels after ectopy is resolved with push dose


SIDE EFFECTS:
Seizures or altered mental status
Suppresses myocardial activity
LORAZEPAM (ATIVAN)
LORAZEPAM (ATIVAN)

PHYSIOLOGICAL ACTIONS:
Raises seizure threshold at neuromuscular junction
Limits propagation of seizure in brain
CNS depressant
Amnestic

THERAPEUTIC EFFECTS:
Anticonvulsant
Sedative to facilitate therapies

INDICATIONS:
Status seizures
Sedation for procedures

CONTRAINDICATIONS:
Pregnancy, except as anticonvulsant for eclamptic seizure refractory to magnesium sulfate

DOSAGE:
Adult:
• Seizure: 2 - 4 mg IV or via buccal mucosa if IV unobtainable, may repeat once in 10 minutes
• Sedation: 2 mg IV, may repeat once in 10 minutes

Pediatric:
• Seizure: 0.1mg/kg IV or via buccal mucosa if IV unobtainable, max single dose 2 mg, may repeat once in 10 minutes
• Sedation: 0.1 mg/kg IV, max single dose 2 mg

ROUTE:
IV/IO
Buccal Mucosa

SPECIAL NOTES:
Must be stored between 35 and 45F.
For IV dose, dilute with equal quantity of NS, administer at rate of 2 mg/minute
For administration via buccal mucosa, do not dilute
Dose is individualized to each patient, use the minimal amount necessary to achieve the theraputic response desired
Titrate to desired effect while closely observing for respiratory depression

SIDE EFFECTS:
Respiratory depression
MAGNESIUM SULFATE
MAGNESIUM SULFATE

PHYSIOLOGICAL ACTIONS:
Nervous system depressant

THERAPEUTIC EFFECTS:
Raises seizure threshold
Decreases BP through vasodilation
Anti-convulsant
Corrects some ventricular dysrhythmias (Torsades de Pointes, etc.)
Smooth muscle relaxant

INDICATIONS:
Toxemia of pregnancy (eclampsia and preeclampsia)
Hypomagnesemic induced ventricular irritability
Torsades de Pointes
Refractory V-Fib
Asthma refractory to other treatments

CONTRAINDICATIONS:
Heart block

DOSAGE:
Toxemia:
• 2 G IV and 2 G IM

Pulseless Dysrhythmias:
• 2 G IV

Perfusing Dysrhythmias/Asthma:
• 2 G (4 ml) diluted in 6 ml IV fluid (total volume of 10 ml) over 1-2 min slow push

ROUTE:
IV/IO
IM
IV/IO infusion

SPECIAL NOTES:
Give slowly (over ~2 minutes) when used IV/IO on perfusing patients
Used with caution in AMI

SIDE EFFECTS:
Hypotension
CNS or respiratory depression
METHYLPREDNISOLONE (SOLUMEDROL)
METHYLPREDNISOLONE (SOLUMEDROL)

PHYSIOLOGICAL ACTIONS:
Suppresses immune reactions

THERAPEUTIC EFFECTS:
Reduces or inhibits allergic reactions
Reduces or inhibits asthma attacks and exacerbation of COPD

INDICATIONS:
Allergic reactions
Severe, refractory asthma
Severe, refractory exacerbation of COPD

CONTRAINDICATIONS:
Systemic fungal infections

DOSAGE:
Adult:
• 125 - 250 mg

Pediatric:
• 2 - 3 mg/kg, max dose of 125 mg

ROUTE:
IV
IM

SPECIAL NOTES:
Onset of action is 30 minutes to 1 hour
Effects may last up to 48 hours

SIDE EFFECTS:
None in the acute setting
MIDAZOLAM (VERSED)
MIDAZOLAM (VERSED)

PHYSIOLOGICAL ACTIONS:
CNS depressant
Amnestic

THERAPEUTIC EFFECTS:
Sedative to facilitate therapies
Chemical Restraint

INDICATIONS:
Sedative / amnestic for procedures which would cause discomfort to the patient
Sedative to facilitate orotracheal intubation
Status seizure refractory to lorazepam
Status seizure patient without IV access
Violent patients requiring chemical restraint

CONTRAINDICATIONS:
Pregnancy, except as anticonvulsant for eclamptic seizure refractory to magnesium sulfate and lorazepam.

DOSAGE:
Sedation: 0.05 - 0.1 mg/kg IV, titrated to effect up to 10 mg
Intubation: 0.1 - 0.3 mg/kg IV, titrated to effect up to 20 mg
Seizure: 0.1 mg/kg IV or 0.3 mg/kg IN up to 5 mg
Chemical Restraint: 0.1 mg/kg IV up to 5 mg, or IM up to 10 mg

ROUTE:
IV/IO
IM
IN

SPECIAL NOTES:
Since midazolam can cause significant hypotension, its use in the hypotensive patient for rapid sequence induction/intubation should be used with extreme caution and titrated to effect.
Dose is individualized to each patient
Titrate to desired effect while closely observing for respiratory depression or hypotension

SIDE EFFECTS:
Respiratory depression
Hypotension
MORPHINE SULFATE
MORPHINE SULFATE

PHYSIOLOGICAL ACTIONS:
Depresses CNS functions
Induces vasodilation (both arterial and venous)
Reduces both preload and systemic vascular resistance (afterload)

THERAPEUTIC EFFECTS:
Analgesia
Vasodilation, with resulting increase in myocardial perfusion, decrease in myocardial work, reduction in pulmonary edema

INDICATIONS:
Relief of severe pain
Myocardial ischemia
Pulmonary edema

CONTRAINDICATIONS:
Head injury
Altered mentation
Hypotension
Respiratory depression/failure

DOSAGE:
Adult: 2 - 20 mg in increments of 2 mg.

Pediatric: 0.1 - 0.2 mg/kg in increments of 0.05 mg/kg
• Max. single dose of 2 mg

ROUTE:
IV
IM
SQ

SPECIAL NOTES:
Respiratory depression secondary to MS can be reversed with naloxone
Promethazine may be used to reduce nausea associated with MS
Promethazine will increase effects of MS

SIDE EFFECTS:
CNS/respiratory depression
Hypotension
N/V
Bradycardia
Diaphoresis
NALOXONE (NARCAN)
NALOXONE (NARCAN)

PHYSIOLOGICAL ACTIONS:
Competitively blocks opiate receptors

THERAPEUTIC EFFECTS:
Reduces or reverses intoxication from narcotics, synthetic narcotics, alcohol, and other substances

INDICATIONS:
Known or suspected narcotic overdose
Altered mentation of unknown etiology

CONTRAINDICATIONS:
None.

DOSAGE:
Adult: 0.5 – 2.0 mg IV, may administer up to 8 mg
• OR 2.0 mg IN (1 mg per nostril) if IV route is delayed or not available
• OR 2.0 mg IM if IV or IN routes are delayed or not available

Pediatric: 0.1 mg/kg IV up to 2 mg single dose.

ROUTE:
IV
ET
IM
IN

SPECIAL NOTES:
Substances other than narcotics and opiates will respond to naloxone, but require relatively high doses

SIDE EFFECTS:
Withdrawal symptoms in addicted patients
Agitation or combativeness
NITROGLYCERINE (NITROSTAT/NTG
NITROLINGUAL)
NITROGLYCERINE (NITROSTAT/NTG/NITROLINGUAL)


PHYSIOLOGICAL ACTIONS:
Smooth muscle relaxant

THERAPEUTIC EFFECTS:
Vasodilation
Reduction in BP
Coronary artery dilation

INDICATIONS:
Myocardial ischemia
Pulmonary edema

CONTRAINDICATIONS:
Hypotension
Hypovolemia
Increased ICP
Patient’s use of medication for erectile dysfunction within the past 48 hours

DOSAGE:
0.4 mg pre-metered spray
Repeat every 5 minutes up to 3 doses

ROUTE:
SL

SPECIAL NOTES:
Recheck BP before administering each dose
Occasionally causes sharp reduction in BP
Be prepared to support BP with positioning and fluids

SIDE EFFECTS:
Hypotension
Syncope
Headache
Dizziness
Flushing
Tachycardia
ONDANSETRON (ZOFRAN)
ONDANSETRON (ZOFRAN)

PHYSIOLOGICAL ACTIONS:
Selective serotonin receptor inhibitor
Antiemetic

THERAPEUTIC EFFECTS:
Reduces nausea/vomiting

INDICATIONS:
Nausea

CONTRAINDICATIONS:
Prolonged QT Interval
Severe hepatic disease

DOSAGE:
Adult: 4 mg
• IV administration over 30 seconds

Pediatric: 0.1 mg/kg up to 4 mg
• IV administration over 30 seconds

ROUTE:
IV
IM

SPECIAL NOTES:
Minimal sedative effect
Does not potentiate the effects of Morphine
Promethazine is preferred if the patient is actively vomiting

SIDE EFFECTS:
Headache
Dizziness
Blurred vision
Fever
ORAL GLUCOSE (GLUTOSE, INSTA-GLUCOSE)
ORAL GLUCOSE (GLUTOSE, INSTA-GLUCOSE)

PHYSIOLOGICAL ACTIONS:
Carbohydrate glucose source

THERAPEUTIC EFFECTS:
Raises blood glucose level

INDICATIONS:
Hypoglycemia, established or suspected

CONTRAINDICATIONS:
Decreased mental status (unable to manage PO substances)

DOSAGE:
25 - 80 G of paste

ROUTE:
PO

SPECIAL NOTES:
May be given to patients with altered mental status but intact gag reflex by carefully "smearing" the paste on the oral mucosa
Is distasteful

SIDE EFFECTS:
None
OXYGEN
OXYGEN

PHYSIOLOGICAL ACTIONS:
Increases oxygen tension in blood

THERAPEUTIC EFFECTS:
Reduces or reverses hypoxemia or ischemia

INDICATIONS:
All hypoxic or ischemic patient, known or suspected

CONTRAINDICATIONS:
None

DOSAGE:
Varies with administration device and patient need

ROUTE:
Inhalation

SPECIAL NOTES:
When administering to COPD patients, watch closely for respiratory depression and be prepared to assist ventilations

SIDE EFFECTS:
Drying of mucous membranes if not humidified
PROMETHAZINE (PHENERGAN)
PROMETHAZINE (PHENERGAN)

PHYSIOLOGICAL ACTIONS:
Antihistamine
H1 antagonist
CNS sedative (selective functions)

THERAPEUTIC EFFECTS:
Reduces nausea/vomiting
Potentiates narcotics

INDICATIONS:
Nausea/vomiting

CONTRAINDICATIONS:
Hypotension
Altered mental status

DOSAGE:
Adult: 6.25 - 12.5 mg
• May repeat once in 15 minutes if no relief

Pediatric: 0.5 mg/kg up to 12.5 mg

ROUTE:
IV
IM

SPECIAL NOTES:
Must be diluted in 9 ml’s of NS prior to slow IV administration
If given with MS, will potentiate the effects of the MS
Dose should be reduced to 6.5 mg in elderly patients

SIDE EFFECTS:
Hypotension
Sedation
SODIUM BICARBONATE
SODIUM BICARBONATE

PHYSIOLOGICAL ACTIONS:
Increases systemic pH by binding hydrogen ions

THERAPEUTIC EFFECTS:
Reduces metabolic acidosis
Interferes with the activity of certain drugs (specifically, tricyclic antidepressants)

INDICATIONS:
Metabolic acidosis
Symptomatic tricyclic anti-depressant overdose (with cardiac dysrhythmias or significant mental status change)
Cardiac arrest with suspected hyperkalemia

CONTRAINDICATIONS:
Hypokalemia
Congestive heart failure

DOSAGE:
1.0 mEq/kg, repeat doses are 0.5 mEq/kg at 10 min intervals
Neonates: must receive bicarb at half the adult concentration (4.2 %)
TCA Overdose: 1 mEq/kg initial bolus, followed by 0.05 mEq/ml infusion (50 mEq/1000 ml NS or 25 mEq/500 ml NS) titrated to systolic BP > 90 mmHg.
Crush Injury: Add 50 mEq Sodium Bicarbonate to even numbered liters of IV fluids (i.e. 2nd, 4th, etc.)

ROUTE:
IV

SPECIAL NOTES:
RARELY indicated, except where metabolic acidosis is known or clearly the most probable culprit, such as DKA, ASA, or TCA overdose, ethylene glycol poisoning, etc.
Cardiac arrest patients with a history of renal failure or other factors predisposing them for hyperkalemia should receive bicarb early in the resuscitation.

SIDE EFFECTS:
Volume overload
Cellular acidosis
Hypokalemia
SUCCINYLCHOLINE (ANECTINE)
SUCCINYLCHOLINE (ANECTINE)

PHYSIOLOGICAL ACTIONS:
Neuromuscular blocker

THERAPEUTIC EFFECTS:
Induces paralysis to achieve favorable intubation conditions

INDICATIONS:
Critical need for endotracheal intubation in patient not otherwise able to tolerate the procedure

CONTRAINDICATIONS:
Patients in whom a surgical airway would be difficult or impossible (i.e. massive neck swelling or injury)
Patients who would be difficult to intubate or ventilate after paralysis (i.e. upper airway obstruction, acute epiglottitis)
Hyperkalemia
Neuromuscular disorders (ALS, MS, muscular dystrophy, etc.)
History of malignant hyperthermia

DOSAGE: 2 mg/kg

ROUTE:
IV/IO

SPECIAL NOTES:
Intubation conditions (complete paralysis) obtained in ~45 sec
Duration of paralysis normally ~8 minutes
May cause fasciculations (muscle twitching) prior to paralysis
Must be stored between 35 and 45F, or replaced every 30 days if stored at room temperature

SIDE EFFECTS:
Apnea
Elevated serum potassium
TERBUTALINE (BRETHINE)
TERBUTALINE (BRETHINE)

PHYSIOLOGICAL EFFECTS:
Beta 2 agonist
Smooth muscle relaxant

THERAPEUTIC EFFECTS:
Bronchodilation
Uterine relaxation (inhibition of contractions)

INDICATIONS:
Asthma
Exacerbation of COPD
Premature labor

CONTRAINDICATIONS:
None

DOSAGE:
0.25 mg
• May repeat once in 15 minutes if no relief
• May repeat PRN for premature labor contractions

ROUTE:
SQ
Nebulized inhalation

SPECIAL NOTES:
Generally not used in pediatrics < 35 kg
If administered through nebulized inhalation, dilute in 2.5 ml NS. See Nebulized Bronchodilation procedure

SIDE EFFECTS:
In high doses, may have beta 1 properties (increased heart rate, etc.)
Tremors
Agitation and excitability, especially in pediatric patients
TETRACAINE
TETRACAINE

PHYSIOLOGICAL ACTIONS:
Local ocular anesthesia

THERAPEUTIC EFFECTS:
Provides relief from pain of eye injuries

INDICATIONS:
Corneal Abrasions
Foreign bodies
Chemical irritations of the eye

CONTRAINDICATIONS:
Open or disrupted globe

DOSAGE: 1-2 gtts each eye, repeat every 10 minutes as needed

ROUTE:
Topical

SPECIAL NOTES:
None

SIDE EFFECTS:
May sting or burn initially
THIAMINE
THIAMINE


PHYSIOLOGICAL ACTIONS:
Allows glucose metabolism
Protects nervous system from hypertonic insult

THERAPEUTIC EFFECTS:
Allows D50% administration in malnourished or de-myelinated patients
Prevents or reverses Wernicke's encephalopathy

INDICATIONS:
Chronic alcoholism or suspected malnutrition
Altered mentation of unknown etiology
Prior to D50% administration to patients in whom alcohol abuse history cannot be ruled out

CONTRAINDICATIONS:
None

DOSAGE: 100 mg

ROUTE:
IV
IM

SPECIAL NOTES:
If used with dextrose, MUST PRECEDE D50% or oral glucose gel

SIDE EFFECTS:
None
VECURONIUM (NORCURON)
VECURONIUM (NORCURON)

PHYSIOLOGICAL ACTIONS:
Neuromuscular blocker, nondepolarizing

THERAPEUTIC EFFECTS:
Maintians paralysis in intubated patients

INDICATIONS:
Critical need for continued paralysis to maintain endotracheal tube in patients undergoing RSI

CONTRAINDICATIONS:
History of malignant hyperthermia
Known hypersensitivity to the drug

DOSAGE: 0.1 mg/kg

ROUTE:
IV/IO

SPECIAL NOTES:
Onset of action (complete paralysis) obtained in 2 ½ to 3 minutes
Duration of paralysis normally 20 - 40 minutes

SIDE EFFECTS:
Apnea
Doses for Midazolam:
DOSAGE:
Sedation: 0.05 - 0.1 mg/kg IV, titrated to effect up to 10 mg
Intubation: 0.1 - 0.3 mg/kg IV, titrated to effect up to 20 mg
Seizure: 0.1 mg/kg IV or 0.3 mg/kg IN up to 5 mg
Chemical Restraint: 0.1 mg/kg IV up to 5 mg, or IM up to 10 mg
Doses for Lorazopam:
DOSAGE:
Adult:
• Seizure: 2 - 4 mg IV or via buccal mucosa if IV unobtainable, may repeat once in 10 minutes
• Sedation: 2 mg IV, may repeat once in 10 minutes

Pediatric:
• Seizure: 0.1mg/kg IV or via buccal mucosa if IV unobtainable, max single dose 2 mg, may repeat once in 10 minutes
• Sedation: 0.1 mg/kg IV, max single dose 2 mg

Must be stored between 35 and 45F.
For IV dose, dilute with equal quantity of NS, administer at rate of 2 mg/minute
For administration via buccal mucosa, do not dilute
Dose is individualized to each patient, use the minimal amount necessary to achieve the theraputic response desired
Titrate to desired effect while closely observing for respiratory depression