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98 Cards in this Set
- Front
- Back
|
cell have
|
surface recognition site taht maintain organization(experiemnt)
|
|
|
light micrograph
|
mixed pre-cartilage cells from a chick limb and chick heart
|
|
|
ectoderm and mesoderm
|
reassociate after initial random dissociation
|
|
|
cell-cell interaction are prominent in
|
epithelial tissues
|
|
|
molecules responsible for cell-cell interaction
|
cadherin, IGSF, integrin, selectin
|
|
|
human disease
|
bullous pemphigoid, autoimmunie disease, 2) epidermolysis bullosa, genetic disesse for hemidesmosomal proteins
|
|
|
cadherin
|
glycoproteins that mediate Ca2+ dependent cell-cell adhesion
|
|
|
e-cadherin
|
epithelial
|
|
|
n cadherin
|
neural
|
|
|
p cadherin
|
placental
|
|
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EMT
|
mediate many of hte changes in adhesive contacts during embryonic developement
|
|
|
embryogenesis
|
cells gain adn lose specific adhesisve properties
|
|
|
epithelia
|
tight association
|
|
|
mesenchyme
|
loose association
|
|
|
development of hte neural tube
|
e-cadherin expression in epitheliuum
|
|
|
N cadherin expression in
|
neural tube cells.
|
|
|
cytoplasmic domain of hte cadherin molecule
|
connected to the actin filaments of the cytoskeleton
|
|
|
b caternin
|
key element in a signaling pathway leading from the cell surfacve to the cell nucleus
|
|
|
adherens junctions
|
form belts near apical surface
|
|
|
cells fo an adherens junction held together by
|
calcium dependent linkages.
|
|
|
desmosomes
|
disked shaped adhesive junction between cells 1) found in variety of tissues, 2) contain cadherin that link two cells across a narrow gap 3) have different domain structures
|
|
|
pemphigus vulgaris
|
loss of cell-cell contact/blistering
|
|
|
Immunoglobulin superfamily
|
involved in immune functions
|
|
|
most IgSF molecules
|
mediate interaction of lymphocytes with cells required or immune responce
|
|
|
IgSF includes
|
VCAM, NCAM, L1
|
|
|
transmembrane signaling
|
transfer of information across plama membrane
|
|
|
integrins and cadherins can
|
trasmit signals from teh extracellular encironment to the cytoplasm
|
|
|
binding of an integrin wtih its ligand
|
induce a responses such as changes in growth potential
|
|
|
tight junction
|
specialized contact between epithelial cell, 1) locate at very apical end, 2) serve as barrier to free diffusion of water adn soltue, 3) some are permeable to specific ions or solute
|
|
|
occludins
|
proteins found in TJs
|
|
|
claudin
|
form teh major structural components of TJs, and accoutn for selective differences in TJ permeability
|
|
|
TJs form
|
blood brain barrier
|
|
|
claudin 16
|
expressed in kidney tubule
|
|
|
claudin 1
|
ko mice die from dehydration from uncontrolled water loss
|
|
|
gap junction
|
sites between animal cells for intercellular communicatiojn
|
|
|
connexin
|
composed entirely of membrane protein
|
|
|
connexon
|
connexins are organized into a complex
|
|
|
selectins
|
family of integral membrane glycoproteins taht bind to sugar ont eh surface of cell
|
|
|
e selectin
|
on endothelial cells
|
|
|
p selectin
|
on platelets and endothelial cells,
|
|
|
l selectin
|
on whtie blood cells
|
|
|
inflammation
|
response to infection or injury
|
|
|
responce
|
recruitment of leukocyte to stie of injuryh 2) neutrophils attach to p adn e selectin 3) netutrophils star to roll along wall of vessel
|
|
|
neutrophils
|
interact wtih inflamed venule endothelium PAF
|
|
|
PAF sends
|
signal to increase teh binding activity of soem integrins
|
|
|
activated integrins cause neutrophils to
|
stop roling and adhere firrmly to wall of vessel
|
|
|
cancer
|
result of abnormal cell proliferation
|
|
|
metasstasis
|
spread of tumor to other parts of body
|
|
|
metasttic cell have
|
1) are elss adhesive, able to penetrate several barriers, able to invade normal cells.
|
|
|
cell have
|
surface recognition site taht maintain organization(experiemnt)
|
|
|
light micrograph
|
mixed pre-cartilage cells from a chick limb and chick heart
|
|
|
ectoderm and mesoderm
|
reassociate after initial random dissociation
|
|
|
cell-cell interaction are prominent in
|
epithelial tissues
|
|
|
molecules responsible for cell-cell interaction
|
cadherin, IGSF, integrin, selectin
|
|
|
human disease
|
bullous pemphigoid, autoimmunie disease, 2) epidermolysis bullosa, genetic disesse for hemidesmosomal proteins
|
|
|
cadherin
|
glycoproteins that mediate Ca2+ dependent cell-cell adhesion
|
|
|
e-cadherin
|
epithelial
|
|
|
n cadherin
|
neural
|
|
|
p cadherin
|
placental
|
|
|
EMT
|
mediate many of hte changes in adhesive contacts during embryonic developement
|
|
|
embryogenesis
|
cells gain adn lose specific adhesisve properties
|
|
|
epithelia
|
tight association
|
|
|
mesenchyme
|
loose association
|
|
|
development of hte neural tube
|
e-cadherin expression in epitheliuum
|
|
|
N cadherin expression in
|
neural tube cells.
|
|
|
cytoplasmic domain of hte cadherin molecule
|
connected to the actin filaments of the cytoskeleton
|
|
|
b caternin
|
key element in a signaling pathway leading from the cell surfacve to the cell nucleus
|
|
|
adherens junctions
|
form belts near apical surface
|
|
|
cells fo an adherens junction held together by
|
calcium dependent linkages.
|
|
|
desmosomes
|
disked shaped adhesive junction between cells 1) found in variety of tissues, 2) contain cadherin that link two cells across a narrow gap 3) have different domain structures
|
|
|
pemphigus vulgaris
|
loss of cell-cell contact/blistering
|
|
|
Immunoglobulin superfamily
|
involved in immune functions
|
|
|
most IgSF molecules
|
mediate interaction of lymphocytes with cells required or immune responce
|
|
|
IgSF includes
|
VCAM, NCAM, L1
|
|
|
transmembrane signaling
|
transfer of information across plama membrane
|
|
|
integrins and cadherins can
|
trasmit signals from teh extracellular encironment to the cytoplasm
|
|
|
binding of an integrin wtih its ligand
|
induce a responses such as changes in growth potential
|
|
|
tight junction
|
specialized contact between epithelial cell, 1) locate at very apical end, 2) serve as barrier to free diffusion of water adn soltue, 3) some are permeable to specific ions or solute
|
|
|
occludins
|
proteins found in TJs
|
|
|
claudin
|
form teh major structural components of TJs, and accoutn for selective differences in TJ permeability
|
|
|
TJs form
|
blood brain barrier
|
|
|
claudin 16
|
expressed in kidney tubule
|
|
|
claudin 1
|
ko mice die from dehydration from uncontrolled water loss
|
|
|
gap junction
|
sites between animal cells for intercellular communicatiojn
|
|
|
connexin
|
composed entirely of membrane protein
|
|
|
connexon
|
connexins are organized into a complex
|
|
|
selectins
|
family of integral membrane glycoproteins taht bind to sugar ont eh surface of cell
|
|
|
e selectin
|
on endothelial cells
|
|
|
p selectin
|
on platelets and endothelial cells,
|
|
|
l selectin
|
on whtie blood cells
|
|
|
inflammation
|
response to infection or injury
|
|
|
responce
|
recruitment of leukocyte to stie of injuryh 2) neutrophils attach to p adn e selectin 3) netutrophils star to roll along wall of vessel
|
|
|
neutrophils
|
interact wtih inflamed venule endothelium PAF
|
|
|
PAF sends
|
signal to increase teh binding activity of soem integrins
|
|
|
activated integrins cause neutrophils to
|
stop roling and adhere firrmly to wall of vessel
|
|
|
cancer
|
result of abnormal cell proliferation
|
|
|
metasstasis
|
spread of tumor to other parts of body
|
|
|
metasttic cell have
|
1) are elss adhesive, able to penetrate several barriers, able to invade normal cells.
|
