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32 Cards in this Set
- Front
- Back
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Aminoglycosides |
Streptomycin Tobramycin Gentamicin Amikacin |
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Tetracyclines |
own category--inhibitors of bacterial ribosomes |
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Most used tetracyclines |
doxycycline and minocycline |
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Tetracyclines orally available,_______ spectrum with activity against gram _____ and gram ______ organisims. aerobic and anerobic. Also numerous atypicals |
broad, +, - |
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Particularly effective against spirochetes |
Tetracyclines |
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Modified tetracyclines that are less affected by tetracycline resistance schemes |
Glycylcyclines |
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Reduce affinity for efflux pumps. different and important properties |
Glycylcyclines |
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The only approved glycyclcycline and is avaliable as a parenteral only |
tigecycline |
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Tetracycline and tigecycline use |
respiratory infections, syphilis, MRSA, and acne |
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Agent of choice for rickettsial infections |
doxycycline |
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Tetracyclines are _____ inhibitors that bind reversibly to the _____ ribosomal subunit. |
bacteriostatic, 30s |
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Prevent biding of aminoacyl-tRNA to the ribosomal acceptor site |
tetracyclines |
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Most clinically relevant involves decreased drug accumulation due to decreased influx and increased efflux of drug |
tetracycline resistance |
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Most tetracycline resistance involves _____ accumulation of drug. ____ efflux and _____ uptake |
decrease, increase, decrease |
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Tetracycline ADME |
distributes to all tissues and secretions. also cross bbb and placenta and also accumulate in breast milk. DO NOT require adjustment for renal failure. |
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Tetracyclines are subject to ____________ ____________ which causes persistent drug levels after dosing ends. |
Enterohepatic recirculation |
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Enterohepatic recirculation |
drug goes to liver then bile then lumen of SI and gets picked up and reabsorbed again |
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drug most often used in large part to a convenient pharmacokinetic profile. Less likely to cause toxicity. |
Doxycycline |
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Can be used for MSSA and MRSA |
Minocycline and tigecycline |
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Effective against respiratory pathogens including Stretococcus, Haemophilus, Mycoplasma, and Chlamydophila |
Doxycycline |
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Drug of choice for Rickettsia, Chlamydia, Mycoplasma |
Doxycycline |
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Good activity against spirochetes, Borrelia, Treponema, Leptospira |
Tetracycline |
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Doxycycline + Ceftriaxone |
used for gonorrhea |
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This has the broadest spectrum and retains efficacy against many of this drugs resistant strains |
tigecycline |
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has activity against + bacteria like streptococcus, enterococcus, and vancomycin-resistant enterococci, MSSA and MRSA |
tigecycline |
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susceptible gram negatives include Acinetobacter, Enterobacter, E-coli, Klebsiella, and others |
tigecyclin |
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Most common adverse effect in pts taking tetracyclines |
GI upset |
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Pregnancy Category: ____ for tetracycline |
D |
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Degraded (expired) tetracyclines can cause ___ where the proximal tubule fails to reabsorb glucose, AAs, uric acid, phosphate, and bicarb |
Fanconi syndrom |
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Can discolor permanent teeth b/4 child grows |
tetracyclines |
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Black boxed for increased mortality |
Tigecycline |
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Can tetracyclines and penicillins be combined? |
NO |
