Lecture 5 Objectives

Front 1

MOA of Muromonab

Back 1

Binds to CD3 antigen of T-lymphocytes, which inactivates it and decreases CD3 levels, resulting in a decrease of transplant rejection

Front 2

MOA of basiliximab

Back 2

Inhibits IL-2 mediated T-lymphocyte activation, resulting in a decreased risk of transplant rejection

Front 3

Cytokine Release syndrome
a.) what is it?
b.) what drug?
c.) role it plays in drug use

Back 3

a.) dangerous ADR. symptoms range from the flu to very severe life-threatening shock reactions
b.) muromonab-CD3, in the first 2-3 doses
c.) cytokine release syndrome limits the use of muromonab-CD3. only a physician trained in immunosuppressant treatment management of organ transplants can administer muromonab-CD3.

Front 4

Gemtuzumab ozogamicin
a.) why was it withdrawn from the market?

Back 4

Gemtuzumab ozogamicin caused hepatic veno-occlusive disease, meaning that the liver veins got blocked. This is a fatal side-effect.

Front 5

Zevulin
a.) radionuclide chelator or drug?
b.) binding
c.) generic name

Back 5

a.) radionuclide chelator
b.) Y-90 & In-111
c.) Ibritumomab tiuxetan (NHL)

Front 6

Bexxar
a.) radionuclide chelator or drug?
b.) binding
c.) generic name

Back 6

a.) radionuclide chelator COMBO
b.) I-131 & non-radiolabeled form
c.) 131 I-tositumomab (NHL)

Front 7

Adcetris
a.) radionuclide chelator or drug?
b.) what
c.) generic

Back 7

a.) drug
b.) monomethyl auristatin E (MMAE)
c.) brentuximab vedotin

Front 8

Kadcyla
a.) radionuclide chelator or drug?
b.) what
c.) generic

Back 8

a.) drug
b.) cytotoxic DM1 moeity/ microtubule inhibitor. also a conjugate of trastuzumab
c.) ado-trastuzumab

Front 9

1.) what does B-CLL stand for?
2.) which drugs are indicated for B-CLL? (2)

Back 9

1.) beta-cell chronic lymphocytic leukemia
2.) A&O: alemtuzumab and obinutuzumab

Front 10

Alemtuzumab
a.) indication
b.) target
c.) ADR

Back 10

a.) B-CLL (beta-cell chronic lymphocytic leukemia)
b.) CD52
c.) blood toxicities

Front 11

Obinutuzumab
a.) indication
b.) target
c.) ADR (2)

Back 11

a.) B-CLL (beta-cell chronic lymphocytic leukemia)
b.) CD20
c.) PML (progressive multifocal leukoencephalopathy) and hep B reactivation

Front 12

Abciximab
a.) indication
b.) target
c.) ADR (2)

Back 12

a.) adjunctive treatment in heart surgeries
b.) receptor of GP-IIa/IIIb, the major receptor in platelet aggregation
c.) bleeding, thrombocytopenia

Front 13

1.) what does NHL stand for?
2.) which drugs are for NHL? (3)

Back 13

1.) non-Hodgkin's lymphoma
2.) Rituximab, Ibritumomab tiuxetan, Tositumomab

Front 14

Rituximab
a.) indication (2)
b.) target
c.) ADR

Back 14

a.) NHL (non-Hodgkin's lymphoma), RA (rheumatoid arthritis)
b.) CD20 antigen (like obinuzumab and the other NHL drugs)
c.) TRIPS - tumor lysis syndrome, reactivation of hep B, infusion reaction, PML, skin reactions

Front 15

Ibritumomab tiuxetan
a.) brand
b.) indication
c.) target
d.) ADR (2)

Back 15

a.) Zevulin (Y-90 & In-111)
b.) NHL (non-Hodgkin's lymphoma)
c.) CD20 antigen (like obinuzuman and other NHL drugs)
d.) cytopenias & skin (Y-90, rituximab combo)

Front 16

Tositumomab
a.) indication
b.) target
c.) ADR

Back 16

a.) NHL (non-Hodgkin's lymphoma)
b.) CD20 antigen
c.) cytopenias

Front 17

TRIPS
a.) for
b.) what

Back 17

a.) rituximab ADRs
b.) TRIPS
Tumor lysis syndrome (leads to renal failure & death)
Reactivation of hep B (like obinuzumab)
Infusion reactions
PML (like obinuzumab)
Skin reactions (like ibritumomab tiuxetan/ zevulin)

Front 18

CD20 target (4)

Back 18

1.) obinuzumab
the NHL drugs
2.) rituximab
3.) ibritumomab tiuxetan (zevulin)
4.) tositumomab (bexxar)

Front 19

PML (2)

Back 19

1.) obinuzumab
2.) rituximab

Front 20

cytopenias (3)

Back 20

1.) tositumomab (bexxar)
2.) ibritumomab tiuxetan (zevulin)
3.) maybe alemtuzumab (blood toxicologies)

Front 21

skin reactions (2)

Back 21

1.) ibritumomab tiuxtein (zevulin)
2.) rituximab

Front 22

Which drugs are for breast cancer? (4)

Back 22

1.) trastuzumab
2.) ado-trastuzuman emtansine
3.) pertuzumab
4.) bevacizumab

Front 23

Trastuzumab
a.) indication (2)
b.) target
c.) ADR

Back 23

a.) breast cancer & metastatic gastric cancer
b.) HER-2/neu
c.) cardiomyopathy/ CHF

Front 24

Ado-trastuzumab emtansine
a.) indication
b.) target
c.) ADR
d.) brand

Back 24

a.) breast cancer
b.) HER-2
c.) ado in the CLuB: Cardiotoxicity, liver toxicity, babies (embryo-fetal toxicity)
d.) Kadcyla - cytotoxic DMI moiety -> microtubule inhibitor

Front 25

Pertuzumab
a.) indication
b.) target
c.) ADR (2)

Back 25

a.) breast cancer
b.) HER-2
c.) LV dysfunction, embryo-fetal toxicity

Front 26

Which breast cancer drugs cause baby toxicity? (2)

Back 26

1.) ado-trastuzumab emtansine
2.) pertuzumab

Front 27

Which targets neu?

Back 27

Trastuzumab (also targets HER-2)

Front 28

Which drugs are for colon cancer? (4)

Back 28

Colon cancer:

Cetuximab
Bevacizumab
Panitumomab
Ziv-aflibercept

Front 29

Cetuximab
a.) indication
b.) target
c.) ADR

Back 29

a.) colon cancer
b.) EGFR (epidermal growth factor receptor) like panitumumab
c.) n/a

Front 30

Bevacizumab
a.) indication
b.) target
c.) ADR (2)

Back 30

a.) colon cancer & breast cancer
b.) VEGF (vascular endothelial growth factor) like ziv-aflibercept
c.) wounding healing problems & hemorrhage

Front 31

Panitumumab
a.) indication
b.) target
c.) ADR

Back 31

a.) colon cancer for patients with a wild-type KRAS status (for longer drug duration)
b.) EGFR (like cetuximab)
c.) dermatologic toxicities like skin rashes, as well as more severe forms like sepsis and septic death

Front 32

Ziv-aflibercept
a.) indication
b.) target
c.) ADRs (4)

Back 32

a.) colon cancer
b.) VEGF-A & VEGF-B (like bevacizumab)
c.) wound healing problems, hemorrhaging, fertility impairment, GI perforation

Front 33

1.) Which colon drugs target EGFR?
2.) Which colon drugs target VEGF?

Back 33

1.) cetuximab, panituzumab
2.) ziv-aflibercept, bevacizumab

Front 34

Which drugs requires the patient to be HER-2 positive before use?

Back 34

Trastuzumab

Front 35

Which drug requires the patient to have wild-type KRAS status before use?

Back 35

Panitumumab

Front 36

Which drugs causes wound healing problems & hemorrhaging? (2)

Back 36

1.) Bevacizumab
2.) Ziv-aflibercept

Front 37

Which colon cancer drug causes fertility impairment?

Back 37

Ziv-aflibercept

Front 38

Ipillimumab
a.) indication
b.) target
c.) ADR

Back 38

a.) melanoma
b.) CTLA-4 (lymphocyte antigen)
c.) n/a

Front 39

Which drug is for melanoma?

Back 39

Ipilimumab

Front 40

Which 2 drugs increase the chance of getting cardiomyopathy when used with trastuzumab?

Back 40

1.) paclitaxel
2.) anthracycline + cyclophosphamide