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14 Cards in this Set
- Front
- Back
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Findings from the NHANES study revealed what connection between sxs of metabolic syndrome
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high BP correlated with high cholesterol and high cholesterol correlated with high BP
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Which body shape is most at risk for development of metabolic syndrome
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apple shape, central abdominal obesity
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Describe the euglycemic insulin clamp technique
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used to measure insulin resistance, insulin is infused at a constant rate, glucose is infused at various rates until equilibrium is established. A slower rate indicates insulin resistance
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What did the pioglitazone in DAHL-S salt sensitve hypertensize rats show?
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Using drugs to increase insulin sensitivity decreased blood pressure, demonstrated linked between insulin resistance and high bp
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Describe the phenotype of insulin receptor knockout mice. What evidence did this provide concerning the cause of metabolic syndrom
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Mice lacking the insulin receptor had hypertension, high TG, low HDL, and impaired endothelium dependent vasodilation
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Describe the association of insulin resistance with the determinates of arterial pressure
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-increased HR
-decreased SV -decreased CO -increased PR overall effect is increased arterial pressure |
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The prothromobotic manifestations of metabolic syndrome include
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-decreased plasminogen activator and increased activator inhibitor
-increased fibrinogen -increased blood viscosity |
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In addition to the "deadly quartet" of sxs such as hypertension and dislipidemia, metabolic syndrome is associated with which disorders affecting "peripheral systems"
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-NASH
-PCOS -obstructive sleep apnea -asthma -gallstones |
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Describe the changes in adiopokines/ inflammatory markers that are associated with metabolic syndrome
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increase in: leptin, resistin, interluekins, TNF, C reative protein
decrease in-adiponectin (anti-atherogenic) |
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What are the criteria for Dx'ing metabolic syndrome
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3 or more of:
central obesity triglycerides >150 HDL <40 men, <50 women hypertension >130/85 fasting glucose >110 |
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How does the prevalence of metabolic syndrome vary with age
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20-29 7%
60-69 44% >70 42% |
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The most important aspect of treatment for metabolic syndrome is
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weight reduction (caloric restriction, therapy, activity, drugs, surgery)
**just at 10% reduction is beneficial!! |
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What are the dietary goals of Tx for meatbolic syndrome
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-<7% of calories from saturted fat
-cholesterol <200mg/day -limit trans fats <6gm saltday -restrict alcohol |
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What drugs can be used to Tx metabolic syndrome
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-weight loss drugs (appetite/absportion)
-statins -bile acid sequestrants -fenogibrate to increase HDL (?) -antihypertensives |
