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17 Cards in this Set
- Front
- Back
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Eukaryotic DNA polymerase alpha
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Initiation of replication
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Eukaryotic DNA polymerase delta and/or epsilon
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Elongation of synthesized strand
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Strand elongation direction
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5' to 3'
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Semi-conservative
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1 strand of the double strand conserved in offspring.
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Origin
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Place of DNA replication initiation
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Deoxy
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Missing OH group at 2' position of pentose sugar
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Leading / continuous strand
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Synthesis isn't stopped as it is happening in the same direction as the replication fork is opening.
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Lagging/ discontinuous strand
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Synthesized DNA constantly replaced as more template strand is exposed
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Prokaryotic DNA polymerase III
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Chromosome replication
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Prokaryotic DNA polymerase I
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RNA primer removal. DNA repair.
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Prokaryotic DNA polymerase II, IV & V
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Repair
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No. of Eukaryotic polymerases
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>15 polymerases
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Nicked DNA
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Break in a single strand allowing attachment of primer
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Primer
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Primes DNA strand for replication by creating a few initial bases of RNA
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Polymerase thumb
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Binds DNA as it exits
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2'-5' exonuclease
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Gives nick and proofreading
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Polymerase fingers
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Position template. Get stuck if wrong base
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