Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
What are the primary and secondary lymphoid organs?
|
Primary: Thymus, bone marrow
Secondary: Lymph nodes, spleen, MALT, Tonsils |
|
|
What are the functions of primary vs secondary lymphoid tissues?
|
Primary= production, differentiation, education
Secondary=Activation of lymphocytes due to antigen |
|
|
Where does hematopoiesis take place in a fetus?
|
Yolk sac
|
|
|
What is the major function of the thymus?
|
Education of T cells aka T cell maturation
|
|
|
What decreases as the size of the thymus decreases over the course of a persons life?
|
Decrease in CD4+ cells
Loss of immune protection Loss of immune regulation (Regulatory T cells) |
|
|
How do lymphocytes vs DC's with and antigen enter the lymph node?
|
Lymphocytes enter via the HEV's
DC w\ antigen enter via the afferent lymphatic vessel |
|
|
What is the force that drives lymph through the lymphatic system?
|
Muscular contraction and one way valves
|
|
|
Are the lymphatc vessels and systemic circulation 2 seperate networks?
|
No they are linked
|
|
|
What are the 2 functional areas of the spleen and their functions?
|
Red pulp- Old RBC destruction via macrophages(phagocyt)
White pulp- Lymphoid tissue |
|
|
Where in white pulp to the 2 types of lymphoid cells reside?
|
B cells- follicles
T cells- Periarterial Lymphoid sheath(PALS) |
|
|
When is asplenia a major concern?
|
In conditions where the antigen or infection is in circulating in the blood, b\c the blood filters at spleen. Tissue response intact via lymph nodes
|
|
|
What are the 3 bacteria that are of concern in splenia that were given? Tx?
|
Haemophilus influenzae
Streptococcus pneuomonia Nisserria Menigitidis Prophylactic antibiotics Vaccines |
|
|
What are the functions and locations of MALT and other lymphoid associated tissues?
|
Defends mucous lined tissues with large population of B cells, macrophages, granulocytes and mast cells
|
|
|
What is the structural difference between MALT and tonsils?
|
non-encapsulated vs partially encapsulated
|
|
|
What is immune cell trafficking?
|
When immune cells are moved via the blood to tissues and back via lymphatics
|
|
|
What are the 2 components of sucessful cell migration\trafficking?
|
Extravasation\ Chemotaxis
|
|
|
What are the cell adhesion molecules that facilitate extravasation?
|
CAMs=Integrins and Selectins
|
|
|
What are chemokines?
|
Chemotactic molecules that guide neutrophills and lymphocytes to place of inflammation
|
|
|
What are the paths of a lymphocyte through the spleen vs a lymph node?
|
Spleen= splenic artery-marginal sinuses- blood stream
Lymph node- HEV- efferent lymphatic vessel- blood at venous angle |
|
|
What is the pathway of recirculation of naive B and T cells?
|
Through lymph nodes and spleen
|
|
|
Contrast the recirculatory pathways of acivated B and T lymphocytes?
|
Effector T cells go to site of infection
Memory T go to infection site and B cells remain in lymphoid organs to secrete antibodies, some to bone marrow Memory B recirculate through 2ndary lymphoid tiss |
